PMID: 7538056May 1, 1995Paper

Evidence for a CD14+ population of monocytes in inflammatory bowel disease mucosa--implications for pathogenesis

Clinical and Experimental Immunology
M C GrimmW F Doe

Abstract

Lipopolysaccharide (LPS) is abundant in the intestinal lumen. CD14 is the receptor for the LPS-LPS binding protein complex, and its presence on mononuclear phagocytes allows cell activation by pg/ml concentrations of LPS. We have shown that the recently recruited blood monocyte in inflammatory bowel disease mucosa is CD14+. This study examined the expression of CD14 on macrophages in inflamed (n = 13) and uninflamed (n = 7) intestine by immunohistochemistry, and on disaggregated lamina propria mononuclear cells (12 from inflamed, 17 from uninflamed intestine) and peripheral blood mononuclear cells (n = 26) by flow cytometry, using a panel of three MoAbs directed against CD14. Immunohistochemistry revealed that 3.7% of macrophages in uninflamed intestine were CD14+, while 25.1% of macrophages in active inflammatory bowel disease expressed CD14 (P < 0.02). Flow cytometry demonstrated that CD14 expression by macrophages from Crohn's disease and ulcerative colitis was augmented significantly (P = 0.02 and P = 0.01, respectively) compared with uninflamed intestine, with a discrete population of macrophages in inflammatory bowel disease, not present in normal intestine, which strongly expressed CD14. The characteristically high level...Continue Reading

References

Feb 1, 1992·Gastroenterology·W E PullmanW F Doe
Jan 1, 1991·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·R LandmannJ P Obrecht
Nov 1, 1991·The Journal of Clinical Investigation·W P Arend
Dec 1, 1990·Infection and Immunity·D T GolenbockS D Wright
Apr 1, 1991·The Journal of Clinical Investigation·P C LordC E McCall
Sep 21, 1990·Science·R R SchumannR J Ulevitch
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R K AssoianM B Sporn
Feb 1, 1987·The Journal of Clinical Investigation·C F Nathan
Dec 1, 1974·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·I W McLean, P K Nakane
Dec 1, 1993·The Journal of Experimental Medicine·J PuginP S Tobias
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J PuginP S Tobias
Jan 1, 1993·Clinical Immunology and Immunopathology·R P McCabeM G Peters
Apr 1, 1993·Journal of Pediatric Gastroenterology and Nutrition·A D OlsonS Chensue
Jul 1, 1995·Journal of Gastroenterology and Hepatology·M C GrimmW F Doe

❮ Previous
Next ❯

Citations

Oct 1, 1998·The American Journal of Physiology·M ZareieM H Perdue
Feb 24, 1999·Journal of Gastroenterology and Hepatology·L W PowellM C Grimm
Aug 18, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·P D SmithH Kubagawa
Feb 10, 2006·Clinical and Vaccine Immunology : CVI·Benoît DesnuesJean-Louis Mege
Jun 25, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·I PalamarasH P Stevens
Jan 13, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ellen C Ebert
Mar 9, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Taku KobayashiScott E Plevy
Mar 1, 2012·Annals of the New York Academy of Sciences·Michael Pazianas, R Graham G Russell
Aug 14, 2012·American Journal of Reproductive Immunology : AJRI·Amy L JensenPatricia A Pioli
Jul 7, 2017·Immunity, Inflammation and Disease·Felix LasitschkaJutta Schröder-Braunstein
Mar 22, 2018·Frontiers in Pharmacology·Laura Hidalgo-GarciaPer O Anderson
Mar 20, 2004·Clinical and Experimental Immunology·M HausmannG Rogler
Sep 11, 2004·Clinical and Diagnostic Laboratory Immunology·Toshiaki ShimizuNobuhiro Fujii
May 1, 2002·European Journal of Gastroenterology & Hepatology·P D ThomasP J Ciclitira
May 24, 2008·The Journal of Clinical Investigation·Nobuhiko KamadaToshifumi Hibi
Oct 22, 2010·Mucosal Immunology·P D SmithS M Wahl
Oct 26, 2011·Journal of Innate Immunity·Allan McI Mowat, Calum C Bain
May 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew M PlattAllan McI Mowat
Mar 7, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M PazianasR Graham G Russell
Apr 6, 2017·Mucosal Immunology·T JoerisA McI Mowat
Jan 3, 2020·Clinical and Experimental Pharmacology & Physiology·Jalal MoludiMohammad Alizadeh
Nov 1, 1996·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·S LangeI Mattsby-Baltzer
Apr 8, 1998·The American Journal of Physiology·M A MeijssenD K Podolsky
Jun 9, 2001·Journal of Pediatric Gastroenterology and Nutrition·S NaikI R Sanderson
May 22, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·C C WaterhouseA W Stadnyk
Dec 17, 2008·Expert Review of Gastroenterology & Hepatology·Kazuo Tanaka
Jul 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Martin HausmannGerhard Rogler
May 19, 2012·International Journal of Molecular Sciences·Nahla AzzamManal Shalaby
Jan 27, 2020·European Journal of Clinical Pharmacology·Fabio Alessandro FacchiniIvan Monteleone

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.