Evidence for a cell-specific action of Reelin in the spinal cord

Developmental Biology
P E PhelpsTina Wong

Abstract

Reelin, the extracellular matrix protein missing in reeler mice, plays an important role in neuronal migration in the central nervous system. We examined the migratory pathways of phenotypically identified spinal cord neurons to determine whether their positions were altered in reeler mutants. Interneurons and projection neurons containing choline acetyltransferase and/or NADPH diaphorase were studied in E12.5-E17.5 reeler and wild-type embryos, and their final locations were assessed postnatally. While three groups of dorsal horn interneurons migrated and differentiated normally in reeler mice, the migrations of both sympathetic (SPNs) and parasympathetic preganglionic neurons (PPNs) were aberrant in the mutants. Initially reeler and wild-type SPNs were detected laterally near somatic motor neurons, but by E13.5, many reeler SPNs had mismigrated medially. Postnatally, 79% of wild-type SPNs were found laterally, whereas in reeler, 92% of these neurons were positioned medially. At E13.5, both reeler and wild-type PPNs were found laterally, but by E14.5, reeler PPNs were scattered across the intermediate spinal cord while wild-type neurons correctly maintained their lateral location. By postnatal day 16, 97% of PPNs were position...Continue Reading

References

Nov 2, 1977·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J MarianiC Sotelo
Jan 1, 1978·Annual Review of Neuroscience·V S Caviness, P Rakic
Dec 25, 1976·The Journal of Comparative Neurology·V S Caviness
Jul 8, 1992·The Journal of Comparative Neurology·J G ValtschanoffA Rustioni
Jul 1, 1992·Molecular Reproduction and Development·C C Henery, M H Kaufman
Nov 1, 1991·Journal of Neurobiology·J A Markham, J E Vaughn
Jan 1, 1990·The Journal of Comparative Neurology·P E PhelpsJ E Vaughn
Jul 5, 1988·Brain Research·A M StrackA D Loewy
Apr 24, 1995·The Journal of Comparative Neurology·P E Phelps, J E Vaughn
Mar 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·R WettsJ E Vaughn
Jan 1, 1994·The Journal of Comparative Neurology·M A VizzardW C De Groat
Sep 15, 1993·The Journal of Comparative Neurology·R C SpikeH M Johnston
Apr 1, 1993·The Journal of Comparative Neurology·P E PhelpsJ E Vaughn
Jul 1, 1996·Brain Research. Molecular Brain Research·G D'ArcangeloT Curran
May 1, 1997·The European Journal of Neuroscience·S N SchiffmannA M Goffinet
Oct 10, 1997·Journal of Neurobiology·K E Hunter-Schaedle
Oct 23, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Y Ikeda, T Terashima
Jul 4, 1998·Brain Research. Brain Research Reviews·T Curran, G D'Arcangelo
May 1, 1999·Journal of Neuroscience Methods·V de BergeyckC Lambert de Rouvroit
Nov 26, 1999·Neuron·G D'ArcangeloT Curran
Jul 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·J W YipC Capriotti

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Citations

Mar 24, 2004·Journal of Chemical Neuroanatomy·Emma Pérez-CostasMaría Celina Rodicio
Apr 22, 2009·Development, Growth & Differentiation·Yu Katsuyama, Toshio Terashima
Jan 14, 2010·Development, Growth & Differentiation·Hideyuki DekimotoYu Katsuyama
Jan 27, 2011·Development·Elvira KhialeevaEllen M Carpenter
Jun 15, 2013·Cellular and Molecular Life Sciences : CMLS·Cédric Francius, Frédéric Clotman
Jun 18, 2003·The Journal of Comparative Neurology·Verónica Martínez-CerdeñoFrancisco Clascá
Mar 26, 2016·Frontiers in Cellular Neuroscience·Ankita R Vaswani, Sandra Blaess
May 5, 2009·The Journal of Comparative Neurology·Yee Ping YipJoseph W Yip
May 12, 2007·The Journal of Comparative Neurology·Yee Ping YipJoseph W Yip
Feb 19, 2008·The European Journal of Neuroscience·Alin L AkopiansPatricia E Phelps
Sep 22, 2011·The Journal of Comparative Neurology·Katherine D MoorePatricia E Phelps
Nov 21, 2013·The European Journal of Neuroscience·Autumn D AbadescoPatricia E Phelps
Apr 12, 2005·Biological Psychiatry·S Hossein FatemiDavid A Pearce
May 1, 2016·Trends in Neurosciences·Juliette D GodinLaurent Nguyen
Jan 14, 2017·The European Journal of Neuroscience·Griselda M YvonePatricia E Phelps
Dec 4, 2003·The Journal of Comparative Neurology·Marc D KubasakPatricia E Phelps
Jan 30, 2004·The Journal of Comparative Neurology·Yee Ping YipJoseph W Yip
Jun 5, 2003·Nature Reviews. Neuroscience·Fadel Tissir, André M Goffinet
Jul 2, 2003·Journal of Neuropathology and Experimental Neurology·Kimiko DeguchiDawna L Armstrong
Jul 29, 2020·ELife·Ana S MachadoMegan R Carey
Jan 24, 2020·Frontiers in Neuroanatomy·Agnieszka KrzyzanowskaTania Ramos-Moreno
May 13, 2018·The Journal of Comparative Neurology·Takeshi Kaneyama, Ryuichi Shirasaki
Aug 19, 2004·Journal of Cell Science·Kelian ChenBrian W Howell

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