Evidence for a contribution by purines to the neurogenic response of the guinea-pig urinary bladder

European Journal of Pharmacology
D P WestfallJ P O'Donnell

Abstract

In order to determine if ATP contributes as an excitatory transmitter in the guinea-pig bladder, experiments were conducted with ANAPP3, a photoaffinity analogue of ATP, which is an antagonist of adenine nucleotides in several other smooth muscles. With or without photoactivation with visible light, ANAPP3 antagonized contractile responses of in vitro strips of bladder to exogenous ATP. The antagonism was specific in that responses to acetylcholine and KCl were not affected by ANAPP3. Responses of strips of bladder to transmural electrical stimulation were not antagonized by ANAPP3 and were relatively insensitive to atropine. However, combined treatment with ANAPP3 and atropine produced a marked antagonism of the neurogenic response. In experiments with bladders obtained from animals pretreated with 6-hydroxydopamine, the ANAPP3-sensitive component of the neurogenic response was absent. These results suggest that acetylcholine, released from cholinergic nerves, and a purine, released from 6-hydroxy-dopamine-sensitive nerves, are both involved in motor transmission in this tissue.

References

May 1, 1978·British Journal of Pharmacology·G BurnstockL Kasakov
Jan 1, 1975·Journal of Supramolecular Structure·S J Jeng, R J Guillory
Jan 1, 1971·Naunyn-Schmiedebergs Archiv Für Pharmakologie·T H Svensson
Jan 1, 1972·Annual Review of Pharmacology·N Taira
Mar 1, 1971·The Journal of Pharmacy and Pharmacology·B Dumsday
Jan 5, 1981·European Journal of Pharmacology·J S FedanD P Westfall

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Citations

Dec 1, 1986·Cellular and Molecular Neurobiology·M W McCaman, D A McAfee
Apr 6, 1984·European Journal of Pharmacology·P A LonghurstD P Westfall
Oct 1, 1984·European Journal of Pharmacology·I Mackenzie, G Burnstock
Feb 16, 1988·European Journal of Pharmacology·M MachalyP Sneddon
Dec 7, 1989·European Journal of Pharmacology·A Den HertogA Nelemans
Jan 1, 1988·Pharmacology & Therapeutics·T D White
Jan 1, 1984·Progress in Neuro-psychopharmacology & Biological Psychiatry·T D White
Jan 1, 1985·General Pharmacology·G Burnstock, C Kennedy
Jan 1, 1985·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·C G Acevedo, E Contreras
May 1, 1986·Epilepsia·M ColemanA Landgrebe
Mar 30, 2010·Acta Physiologica·G BurnstockA Verkhratsky
Jan 1, 1990·Annals of the New York Academy of Sciences·D P WestfallI L Buxton
Nov 23, 2013·Purinergic Signalling·Geoffrey Burnstock
Jun 3, 2014·Pharmacology & Therapeutics·Violeta N Mutafova-Yambolieva, Leonie Durnin
Jun 1, 1989·British Journal of Pharmacology·T W Stone, N J Cusack
Dec 1, 1987·Journal of Autonomic Pharmacology·C A MaggiP Santicioli
Jul 2, 2019·Biological & Pharmaceutical Bulletin·Keisuke Obara, Yoshio Tanaka
Jan 1, 1990·Annals of the New York Academy of Sciences·J S Fedan, S J Lamport
Mar 1, 1994·The Journal of Urology·P B Patra, D P Westfall
Oct 1, 1988·British Journal of Pharmacology·T HisayamaT Toyoda
Dec 7, 2020·Biochemical Pharmacology·Vera Ralevic
Apr 15, 1984·Biochemical Pharmacology·J S FedanJ P O'Donnell

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