PMID: 6103935Mar 1, 1980Paper

Evidence for a direct anti-inflammatory action of calcitonin: inhibition of histamine-induced mouse pinnal oedema by porcine calcitonin

The Journal of Pharmacy and Pharmacology
R J StrettleG A Buckley

Abstract

Porcine calcitonin (PCT) caused a potent inhibition of histamine-induced vascular leakage in the mouse pinna. These effects were observed at doses of PCT lower than those required to affect plasma calcium concentrations. In contrast PCT did not inhibit responses of the mouse pinna to 5-hydroxytryptamine despite observed falls in plasma calcium concentrations. It would appear that PCT inhibits histamine-induced oedema in the mouse by a direct action which may partially or fully explain the anti-inflammatory action of PCT, observed by other workers, in some acute inflammatory conditions.

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Citations

Jan 1, 1985·Peptides·P GiustiG Borin
Mar 14, 2009·Proceedings of the National Academy of Sciences of the United States of America·Bryan R BecklundHector F Deluca
Jul 1, 1985·Calcified Tissue International·H MulderP L Winckers
Apr 1, 1996·Disability and Rehabilitation·A A Borg
Mar 1, 1993·Bone and Mineral·G ThamsborgO H Sørensen
Aug 1, 1985·Oral Surgery, Oral Medicine, and Oral Pathology·D R Cullum, L W Kline
Jan 1, 1983·Journal of Periodontal Research·J J Lasfargues, J L Saffar
Nov 3, 2011·Scandinavian Journal of Rheumatology·A TrombettiR Rizzoli

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