Evidence for a direct projection from the postrhinal cortex to the subiculum in the rat

Hippocampus
P A NaberF H Lopes da Silva

Abstract

Behavioral data indicate that three of the areas which form the parahippocampal region in the rat, i.e., the entorhinal, perirhinal, and postrhinal cortices, have different, although related functions that also differ from those of the hippocampal formation. These functional differences might be related to differences in connectivity, on the one hand with parts of the association cortex, and on the other with the hippocampal formation. In a previous study, we showed the existence of both a direct and an indirect projection from the perirhinal cortex to areas CA1 and subiculum of the hippocampus. Here we present the result of a second study, demonstrating a similarly organized projection from the postrhinal cortex to the subiculum, comprising both a direct and an indirect route. Electrical stimulation of the postrhinal cortex in vivo evoked field potentials throughout the subiculum and the dentate gyrus. Current source density analysis in both the subiculum and dentate gyrus revealed the presence of sink-source pairs, indicative of a synaptic termination. Based on comparison with the sink-source pairs found after stimulation of the medial entorhinal cortex, we conclude that the connection between the postrhinal cortex and the de...Continue Reading

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Citations

Mar 21, 2009·Nature Reviews. Neuroscience·N M van StrienM P Witter
Dec 25, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Sheng-Jia ZhangMay-Britt Moser
May 11, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laura A LibbyCharan Ranganath
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Sep 2, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Hiroshi UenoTakeshi Ishihara
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Mar 5, 2021·Reviews in the Neurosciences·Maxime Lévesque, Massimo Avoli
May 21, 2021·Neurobiology of Learning and Memory·Elisa M Taylor-YeremeevaSiobhan Robinson

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