Abstract
We investigated whether the retrosplenial and the posterior cingulate cortex (RS-PCC) is functionally impaired in schizophrenia patients. Therefore, we measured functional magnetic resonance imaging (fMRI) signal changes associated with a synonym-judgment task known to activate, among other areas, the RS-PCC. Compared to 12 matched control subjects, 12 schizophrenia patients exhibited reliably weaker activations in the RS-PCC, the dorsolateral prefrontal cortex and the left orbitofrontal cortex (P < 0.05, corrected). Differences in frontal activations are in line with previous studies showing a structurally and functionally affected prefrontal cortex in schizophrenia. The impaired RS-PCC functionality in a semantic task may relate to verbal memory deficits frequently observed in schizophrenia patients, because this region is pivotal for gating information into the medial temporal lobe memory system.
References
Feb 1, 1991·Brain : a Journal of Neurology·P Rudge, E K Warrington
Jul 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K J FristonR S Frackowiak
Jul 1, 1991·Archives of General Psychiatry·A J SaykinP Stafiniak
Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Mar 1, 1971·Neuropsychologia·R C Oldfield
Dec 22, 1994·The Journal of Comparative Neurology·W A Suzuki, D G Amaral
Feb 9, 1999·Journal of Cognitive Neuroscience·J R BinderR W Cox
Apr 9, 1999·Nature Neuroscience·A C NobreM M Mesulam
Sep 19, 2000·Schizophrenia Bulletin·E ArtigesM L Paillère-Martinot
Mar 10, 2001·Human Brain Mapping·B Crespo-FacorroR D Hichwa
May 18, 2001·Trends in Neurosciences·F R SharpS Tomitaka
May 30, 2001·Schizophrenia Research·T T KircherP K McGuire
Oct 12, 2001·Schizophrenia Research·I E SommerR S Kahn
Oct 13, 2001·Schizophrenia Bulletin·L D Selemon
Dec 25, 2002·Neurocase·Cathy J Price, Karl J Friston
Mar 26, 2003·Neurology·G FernándezC E Elger
Citations
May 20, 2006·Experimental Brain Research·Kelly A NewellXu-Feng Huang
Aug 29, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Philippe PichatBernard Scatton
Nov 7, 2009·Cognitive Neuropsychiatry·O J Doughty, D J Done
Aug 9, 2005·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Jennifer W TideyRobert M Swift
Sep 3, 2010·Schizophrenia Bulletin·Neil DawsonJudith A Pratt
Jun 3, 2005·Neuroreport·Eiichi TabuchiHisao Nishijo
Sep 29, 2009·Psychiatry Research·Robyn L BluhmPeter C Williamson
Jul 14, 2007·Schizophrenia Research·Yuan ZhouTianzi Jiang
Mar 11, 2011·Human Brain Mapping·Diana P PrataPhilip K McGuire
Mar 23, 2012·Human Brain Mapping·Andreina PauliPhilip McGuire
Aug 12, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kelly A NewellXu-Feng Huang
Jun 30, 2006·Pharmacology, Biochemistry, and Behavior·Dai-Ying ZuoMasatoshi Tanaka
Nov 3, 2016·Hippocampus·Helena BuchtováŠtěpán Kubík
Jul 1, 2014·World Journal of Radiology·Gianna SepedeFrancesco Gambi
Aug 2, 2005·Neuroreport·Kelly A NewellXu-Feng Huang
May 20, 2016·Learning & Memory·Travis P ToddDavid J Bucci
Mar 17, 2020·Brain and Behavior·Chuanjun ZhuoCe Chen
Sep 26, 2020·Human Molecular Genetics·Donna CosgroveDerek W Morris