PMID: 7582458Jun 1, 1995Paper

Evidence for a functional alpha 1A- (alpha 1C-) adrenoceptor mediating contraction of the rat epididymal vas deferens and an alpha 1B-adrenoceptor mediating contraction of the rat spleen

British Journal of Pharmacology
R P BurtI Marshall

Abstract

1. The alpha 1-adrenoceptor subtype mediating contraction of the rat epididymal vas deferens and rat spleen has been investigated by use of alpha 1-adrenoceptor antagonists that have shown selectivity between the different cloned receptor subtypes. 2. In the rat epididymal vas deferens the potency of noradrenaline and phenylephrine was increased in the presence of neuronal and extra-neuronal uptake blockers, cocaine and beta-oestradiol, but these did not alter that of methoxamine. The order of potency of the agonists in the presence or absence of uptake blockade was noradrenaline > phenylephrine > methoxamine. In the rat spleen the potency of these agonists was not altered in the presence of cocaine and beta-oestradiol, and their order of potency was the same as in the vas deferens. 3. The non subtype selective alpha 1-adrenoceptor antagonist prazosin (up to 1 x 10(-7) M) was found to antagonize contractions to noradrenaline in the vas deferens competitively (pA2 9.2), but only in a non competitive manner in the spleen. Contractions to phenylephrine in the spleen however were competitively antagonized by prazosin (up to 1 x 10(-7) M) with a pA2 of 9.2. This suggests that there is an alpha 1- and a non alpha 1-adrenoceptor respo...Continue Reading

References

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Citations

Aug 10, 2006·Cellular and Molecular Neurobiology·Wentsworth B KennedyLincoln P Edwards
Apr 27, 2000·European Journal of Pharmacology·M B Hussain, I Marshall
Jun 24, 2003·European Journal of Pharmacology·Marcelo CamposAndré S Pupo
Jul 31, 1998·European Journal of Pharmacology·M SatohK Koike
Aug 1, 1998·European Journal of Pharmacology·A S Pupo
Nov 11, 1999·European Journal of Pharmacology·M A SilvaC S Porto
Mar 12, 2002·Bioorganic & Medicinal Chemistry·Dario GiardinàCarlo Melchiorre
Jul 13, 1999·British Journal of Pharmacology·W B StamP R Saxena
Aug 5, 1999·British Journal of Pharmacology·T TaniguchiI Muramatsu
Dec 1, 1999·British Journal of Pharmacology·V Honner, J R Docherty
Apr 27, 2002·British Journal of Pharmacology·Nnaemeka I B AmobiI Christopher H Smith
Sep 1, 1996·British Journal of Pharmacology·X F DengD R Varma
Nov 1, 1996·British Journal of Pharmacology·J M Haynes, S J Hill
Oct 29, 2009·Cellular and Molecular Life Sciences : CMLS·James R Docherty
Jan 24, 2002·Biology of Reproduction·Daniel B C QueirózMaria Christina W Avellar
Sep 2, 2009·Anais Da Academia Brasileira De Ciências·Maria Christina W AvellarCatarina S Porto
Oct 25, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M CamposA S Pupo
Mar 24, 2006·Autonomic & Autacoid Pharmacology·N I B AmobiI C H Smith
May 26, 2004·British Journal of Pharmacology·Naoyuki TakiIkunobu Muramatsu
Sep 14, 2006·Autonomic & Autacoid Pharmacology·K Bagot, R Chess-Williams
Feb 11, 2010·Izvestiia Akademii nauk. Seriia biologicheskaia·L V BerdyshevaB N Manukhin

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