PMID: 8944709Nov 1, 1996Paper

Evidence for a functional link between stress response and vascular control in hepatic portal circulation

The American Journal of Physiology
M BauerR Larsen

Abstract

Heme oxygenase (HO)-derived carbon monoxide (CO) may contribute to vascular control through elevation of guanosine 3',5'-cyclic monophosphate. In the present study, we investigated the functional significance of expression of the isoenzyme HO-1 (heat-shock protein 32) in liver after hemorrhage/resuscitation (H/R) in rats anesthetized with pentobarbital sodium. An increase of mRNA levels for HO-1 was observed at 3 h after resuscitation, followed by induction of the protein at 6 h in pericentral hepatocytes and sinusoidal lining cells. Concomitantly, lower portal resistance was observed in H/R (0.33 +/- 0.060 mmHg.ml-1.min) compared with control rats (0.47 +/- 0.035 mmHg.ml-1.min). Blockade of the HO-CO pathway by tin protoporphyrin-IX (SnPP-IX) led to a transient increase in portal pressure with no effect on portal low in controls, whereas an increase in pressure and a decrease in flow contributed to the sustained increase in portal resistance after H/R. These results indicate that HO contributes to maintenance of hepatic perfusion in vivo under stressful conditions, suggesting a functional link between stress response and vascular control in portal circulation.

Citations

Mar 21, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I BauerM Bauer
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michael Bauer
Oct 4, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Zonghai RuanMatomo Nishio
Mar 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·László SzalayIrshad H Chaudry
Nov 14, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yukihiro YokoyamaIrshad H Chaudry
Aug 22, 2001·American Journal of Physiology. Heart and Circulatory Physiology·B H PannenK K Geiger
Jun 28, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Markus PaxianMark G Clemens
Jul 1, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M MoriH Ishii
Apr 22, 2006·American Journal of Respiratory and Critical Care Medicine·Alexander RaddatzHauke Rensing

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