PMID: 40667Nov 2, 1979

Evidence for a GABAergic projection from the substantia nigra to the ventromedial thalamus and to the superior colliculus of the rat

Brain Research
G Di ChiaraG L Gessa

Abstract

Unilateral intranigral infusion of kainic acid (1.5 microgram) produced neuronal loss in the lateral two-thirds of the nigra while sparing axons en passage. Fink-Heimer silver impregnation revealed dense terminal degeneration in the nigra itself (both in the compacta and in the reticulata) and in areas of non-dopaminergic nigral projection such as the ventromedial (VM) nucleus of the thalamus, the superior colliculus and the reticular formation; only spare terminal degeneration was found in areas of dopaminergic projection such as the caudate and septum. In order to clarify the nature of the transmitter of the nigrothalamic and nigrocollicular neurons, the activity of glutamic decarboxylase (GAD), the marker of cholinergic neurons, was measured in the VM and ventrobasal (VB) thalamus and in the nigra of each side, 7 days after unilateral intranigral injection of kainic acid. GAD activity was reduced significantly in the VM-thalamus (-33%), in the superior colliculus (-40%) and in the substantia nigra (-18%) but not in the VB-thalamus of the lesioned side. CAT remained unchanged in these areas. Similar results were obtained in the thalamus and in the superior colliculus after electrocoagulative lesions of the nigra. The results ...Continue Reading

References

Nov 15, 1978·Experimental Brain Research·K Kultas-IlinskyK R Smith
Oct 21, 1977·Brain Research·A JayaramanM B Carpenter
Mar 5, 1976·Brain Research·J M DeniauC Le Guyader
Jan 1, 1968·The Journal of Comparative Neurology·R L Faull, J B Carman

Citations

Mar 24, 1997·The Journal of Comparative Neurology·S BischoffS Heinemann
Oct 23, 1997·The Anatomical Record·T P MaG A Hoskins
Apr 3, 1999·Synapse·L Matuszewich, B K Yamamoto
Sep 1, 1990·Annals of Neurology·L TurskiK H Sontag
Aug 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·U HavemannK Kuschinsky
Apr 24, 2007·Neurotoxicity Research·Mario Herrera-MarschitzMichel Goiny
Jan 28, 2005·Cellular and Molecular Neurobiology·Renê Oliveira BeleboniNorberto Cysne Coimbra
Nov 11, 1982·Brain Research·S R VincentE G McGeer
Oct 30, 1984·European Journal of Pharmacology·G De SarroC Reavill
Oct 7, 1986·European Journal of Pharmacology·Krystyna OssowskaS Wolfarth
Aug 18, 1980·Life Sciences·S R VincentE G McGeer
Nov 1, 1983·Pharmacology, Biochemistry, and Behavior·D A WeldonK J Nicklaus
Dec 1, 1987·Pharmacology, Biochemistry, and Behavior·W KolasiewiczS Wolfarth
Mar 1, 1988·Pharmacology, Biochemistry, and Behavior·M B WeingerG F Koob
Mar 1, 1986·Brain Research·E Garcia-Rill
Jan 1, 1995·Brain Research. Brain Research Reviews·A Parent, L N Hazrati
May 1, 1983·Behavioural Brain Research·E Kafetzopoulos, G Papadopoulos
Dec 31, 1993·Behavioural Brain Research·Norberto Cysne Coimbra, Marcus Lira Brandão
May 1, 1993·Neuroscience Research·T Hattori
Jan 1, 1980·Progress in Neurobiology·A Dray
Jan 1, 1991·Progress in Neurobiology·L Sivilotti, A Nistri
Jan 1, 1994·Progress in Neurobiology·A DepaulisC Marescaux
Jan 1, 1981·Neuroscience Letters·G ChevalierJ Feger
Sep 1, 1981·Neuroscience Letters·M S Starr, I C Kilpatrick
Feb 24, 1984·Neuroscience Letters·E Rinvik
Oct 28, 1991·Neuroscience Letters·T MoriizumiT Hattori
Jun 1, 1987·Neuroscience·E RinvikJ Storm-Mathisen
Jan 1, 1989·Neuroscience·K J Campbell, Masahiko Takada
Jan 1, 1995·Brain & Development·S L MoshéL L Brown
Feb 11, 2004·Experimental Neurology·Aristea S Galanopoulou, S L Moshé
Jan 22, 2002·Neuroscience and Biobehavioral Reviews·D M ViannaMarcus Lira Brandão
Feb 28, 2002·Behavioural Brain Research·P Grillner, Nicola Biagio Mercuri
May 29, 1998·Progress in Neurobiology·L DanoberC Marescaux
Jan 3, 2001·The European Journal of Neuroscience·T González-HernándezM Rodríguez
Feb 11, 1998·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·S L Moshé
Jan 1, 1991·The European Journal of Neuroscience·I C KilpatrickT P Powell
Dec 22, 1998·Epilepsia·D C SilveiraA G Herzog
Jan 1, 1990·Annals of the New York Academy of Sciences·L A ThompsonJ M Walker
Mar 15, 2014·PLoS Computational Biology·Mingming ChenDezhong Yao
Mar 21, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Agnes L BodorLászló Acsády
Sep 15, 1994·The Journal of Comparative Neurology·G H ClaytonT E Finger
Nov 24, 2011·Brain Research Bulletin·Medine Idrizoglu GulcebiSafiye Çavdar
Sep 11, 2010·Current Opinion in Neurobiology·Joel ShiresMichele A Basso
Feb 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Melville J Wohlgemuth, Cynthia F Moss
Oct 6, 2009·Brain Research Bulletin·Joice Maria CunhaMarcus Lira Brandão
Feb 27, 2010·Progress in Neurobiology·Mario Herrera-MarschitzUrban Ungerstedt
Jan 3, 1983·Brain Research·J A Childs, K Gale
May 24, 1991·Brain Research·P AuroyA Woda
Jul 1, 1987·Experimental Neurology·D S Garant, K Gale
Apr 3, 2004·Physiology & Behavior·Jesus Landeira-Fernandez, Carlos V Grijalva
Nov 3, 1980·Brain Research·C R HouserE Roberts
Jul 1, 1984·The Journal of Comparative Neurology·P J May, W C Hall
Jul 1, 1981·Journal of Neurochemistry·A Nieoullon, N Dusticier
Aug 9, 2005·Neuroscience and Biobehavioral Reviews·Marcus Lira BrandãoRaquel Chacon Martinez
Nov 1, 2005·Environmental Toxicology and Pharmacology·Hanna VinitskayaLudmila Zylinska
Nov 28, 1994·Brain Research·S L MoshéE F Sperber
Jul 23, 1993·Brain Research·I MendezB A Flumerfelt
Aug 5, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Robert H Wurtz
Apr 8, 1982·Brain Research·G Di ChiaraM L Porceddu
Jan 4, 2013·PloS One·Cristina GambardellaOttorino Belluzzi
Jul 6, 2016·ELife·Mario J Lintz, Gidon Felsen
May 15, 2007·Progress in Brain Research·Okihide Hikosaka
Dec 8, 1994·The Journal of Comparative Neurology·N RajakumarB A Flumerfelt
Jan 1, 1986·Movement Disorders : Official Journal of the Movement Disorder Society·J B Penney, A B Young
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J McCulloch, P A Kelly
Jul 1, 1994·Journal of Child Neurology·A K Afifi
Oct 9, 2018·ELife·Arnaud L LaliveAnatol C Kreitzer
Oct 12, 2018·The European Journal of Neuroscience·Masaharu Yasuda, Okihide Hikosaka
Oct 23, 2018·The European Journal of Neuroscience·Bianca SieveritzGordon W Arbuthnott
Aug 1, 1995·The European Journal of Neuroscience·J GrenhoffS W Johnson
Nov 22, 2013·Journal of Neurophysiology·Safraaz MahamedMichele A Basso
Dec 15, 2015·Neuropathology and Applied Neurobiology·Kelly Del Tredici, Heiko Braak
Jan 8, 1986·The Journal of Comparative Neurology·R W RieckJ T Weber
Mar 1, 2019·Frontiers in Systems Neuroscience·Brian C CoeDouglas P Munoz
Jul 1, 1984·The Journal of Pharmacy and Pharmacology·J K ChiversC D Marsden
Jan 1, 1983·The Journal of Comparative Neurology·H E SavakiM J Besson
Nov 1, 1987·Annals of Neurology·J W MillerJ A Ferrendelli
Dec 11, 2017·Brain Structure & Function·Andreas HintzenMarc Tittgemeyer
Aug 4, 2019·Journal of Neurology·Krystyna Ossowska
Jul 10, 1982·The Journal of Comparative Neurology·I GrofovaS T Kitai

Related Concepts

Choline O-Acetyltransferase
Gamma-Aminobutyric Acid, Zinc Salt (2:1)
Glutamate Decarboxylase
Kainate
Nerve Degeneration
Neural Pathways
Substantia Nigra Structure
Optic Lobe, Human
Thalamic Structure
Tyrosine 3-Monooxygenase

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