Evidence for a gene influencing heart rate on chromosome 5p13-14 in a meta-analysis of genome-wide scans from the NHLBI Family Blood Pressure Program

BMC Medical Genetics
J M LaramieR H Myers

Abstract

Elevated resting heart rate has been shown in multiple studies to be a strong predictor of cardiovascular disease. Previous family studies have shown a significant heritable component to heart rate with several groups conducting genomic linkage scans to identify quantitative trait loci. We performed a genome-wide linkage scan to identify quantitative trait loci influencing resting heart rate among 3,282 Caucasians and 3,989 African-Americans in three independent networks comprising the Family Blood Pressure Program (FBPP) using 368 microsatellite markers. Mean heart rate measurements were used in a regression model including covariates for age, body mass index, pack-years, currently drinking alcohol (yes/no), hypertension status and medication usage to create a standardized residual for each gender/ethnic group within each study network. This residual was used in a nonparametric variance component model to generate a LOD score and a corresponding P value for each ethnic group within each study network. P values from each ethnic group and study network were merged using an adjusted Fisher's combining P values method and the resulting P values were converted to LOD scores. The entire analysis was redone after individuals currentl...Continue Reading

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Citations

Jul 20, 2010·Human Molecular Genetics·Mark EijgelsheimChristopher J O'Donnell
Dec 25, 2009·Circulation. Cardiovascular Genetics·Fabio MarroniUNKNOWN EUROSPAN Consortium
Nov 6, 2008·Experimental & Molecular Medicine·Bayasgalan GombojavJeong Sun Seo
Aug 18, 2006·Journal of Hypertension·Daniel A Duprez
Oct 10, 2006·Pediatric Clinics of North America·Julie R Ingelfinger

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Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

GenNet
Genome Scan
HyperGEN
Heterogeneity and Genome Search Meta - analysis ( HEGESMA )
MathType
MERLIN
GENOA

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