Evidence for a high ancestral GC content in Drosophila

Molecular Biology and Evolution
F Rodríguez-TrellesF J Ayala

Abstract

Study of the nucleotide composition in Drosophila, focusing on the saltans and willistoni groups, has revealed unanticipated differences in nucleotide composition among lineages. Compositional differences are associated with an accelerated rate of nucleotide substitution in functionally less constrained regions. These observations have been set forth against the extended opinion that the pattern of point mutation has remained constant during the evolution of the genus. A crucial assumption has been that the most recent common ancestor of the subgenus Sophophora had an elevated GC content. Until now, this assumption has been supported by indirect arguments, consisting of extrapolations from closely related outgroups and limited by the robustness of mathematical descriptions concerning the extensive nucleotide composition differences among sequences. The present study seeks to test the assumption of a high ancestral GC content using realistic representations of the nucleotide substitution process to account for potential biases induced by the heterogeneous GC content of the taxa. The analysis of eight nuclear genes unambiguously corroborates that the common ancestor of Sophophora had an elevated GC content.

References

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Citations

Oct 10, 2006·Genetica·Frédérique Maczkowiak, Jean-Luc Da Lage
May 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·R TarríoF J Ayala
Apr 9, 2009·Molecular Biology and Evolution·Nadia D SinghCharles F Aquadro
Oct 14, 2010·Molecular Biology and Evolution·J R PowellRyan C Garrick
Nov 28, 2007·Genetics·Andreas Heger, Chris P Ponting
Feb 14, 2016·Molecular Biology and Evolution·Tomotaka MatsumotoHiroshi Akashi
Nov 1, 2008·PLoS Genetics·Antigone S DimasEmmanouil T Dermitzakis
Nov 13, 2007·Nature·Drosophila 12 Genomes ConsortiumIain MacCallum

Related Concepts

Metazoa
G+C Composition
Sense Codon
DNA, Double-Stranded
Drosophila
Drosophila melanogaster
Phylogeny
Genes, Insect
Evolution, Molecular

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