Evidence for a large-scale population structure among accessions of Arabidopsis thaliana: possible causes and consequences for the distribution of linkage disequilibrium

Molecular Ecology
Marie-France OstrowskiT Bataillon

Abstract

The existence of a large-scale population structure was investigated in Arabidopsis thaliana by studying patterns of polymorphism in a set of 71 European accessions. We used sequence polymorphism surveyed in 10 fragments of approximately 600 nucleotides and a set of nine microsatellite markers. Population structure was investigated using a model-based inference framework. Among the accessions studied, the presence of four groups was inferred using genetic data, without using prior information on the geographical origin of the accessions. Significant genetic isolation by geographical distance was detected at the group level, together with a geographical gradient in allelic richness across groups. These results are discussed with respect to the previously proposed scenario of postglacial colonization of Europe from putative glacial refugia. Finally, the contribution of the inferred structure to linkage disequilibrium among 171 pairs of essentially unlinked markers was also investigated. Linkage disequilibrium analysis revealed that significant associations detected in the whole sample were mainly due to genetic differentiation among the inferred groups. We discuss the implication of this finding for future association studies in ...Continue Reading

References

May 10, 2000·American Journal of Human Genetics·S A BacanuK Roeder
May 29, 2000·American Journal of Human Genetics·J K PritchardP Donnelly
Jun 3, 2000·Genetics·J K PritchardP Donnelly
Feb 22, 2002·Theoretical Population Biology·J K Pritchard, P Donnelly
Jun 7, 2002·Nature·Massimo Pigliucci
Nov 2, 2002·Molecular Biology and Evolution·Helmi KuittinenMontserrat Aguadé
Dec 21, 2002·Science·Noah A RosenbergMarcus W Feldman
Feb 13, 2003·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·O. LoudetF. Daniel-Vedele
Apr 1, 2004·The Plant Journal : for Cell and Molecular Biology·Heather I McKhannDominique Brunel
Dec 21, 2004·Nature Genetics·Agnar HelgasonKári Stefánsson
May 24, 2005·PLoS Biology·Magnus NordborgJoy Bergelson
Jan 1, 2002·The Arabidopsis Book·Massimo Pigliucci

❮ Previous
Next ❯

Citations

Jan 12, 2010·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Monique DeuG Bezançon
Jul 4, 2009·Bioinformatics·Eric DurandOlivier François
May 17, 2008·PLoS Genetics·Olivier FrançoisNoah A Rosenberg
May 14, 2010·PLoS Genetics·Benjamin BrachiFabrice Roux
May 21, 2010·PLoS Genetics·Daniela VladOlivier Loudet
Jan 30, 2010·International Journal of Molecular Sciences·Valérie LefebvreMylène Durand-Tardif
Jan 14, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Haidong YanYanhong Yan
Dec 24, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhi-Hui GuoXiao Ma
Jul 1, 2009·Molecular Ecology Resources·Gilles Guillot, Filipe Santos
May 22, 2009·Molecular Ecology·Jennifer M ReiningaMichael D Purugganan
Sep 12, 2008·Molecular Ecology Notes·Daniel FalushJonathan K Pritchard
Jul 27, 2012·Ecology and Evolution·Karen E SamisJohn R Stinchcombe
Jun 18, 2010·The Plant Journal : for Cell and Molecular Biology·Michaël MoisonFrançoise Budar
Mar 1, 2010·Molecular Ecology Resources·Johan FogelqvistMartin Lascoux
Feb 20, 2007·Current Biology : CB·Heidi A KuehnePaul D Sniegowski
Jun 26, 2015·PloS One·Carolina Font i ForcadaAngel Fernández i Martí
Sep 7, 2016·BMC Genetics·Nivedita SinghRakesh Singh
Mar 1, 2009·American Journal of Botany·Jesse W BreinholtCatherine L Stephen
Sep 14, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Duccio Cavalieri
Feb 18, 2010·Molecular Systems Biology·Gal Hagit RomanoMartin Kupiec
May 13, 2010·Molecular Systems Biology·Chris Todd Hittinger, Jay R Hesselberth
Sep 25, 2010·Molecular Systems Biology·Eunjee Lee, Harmen J Bussemaker
Dec 2, 2010·Molecular Systems Biology·Itay TiroshNaama Barkai
Oct 4, 2006·Molecular Systems Biology·Tunahan CakirJens Nielsen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.