Evidence for a major role of inhibin in the feedback control of FSH in the male rat

Journal of Reproduction and Fertility
G F WeinbauerE Nieschlag

Abstract

Adult rats (16-18/group) received a single intratesticular injection of 25, 100 or 400 microliters glycerol solution (7:3 in distilled water, v/v). Half of the rats in each group were given implants of testosterone, a testosterone-filled Silastic capsule (1.5 cm length) to provide serum values of testosterone within the normal range. After 1 week all animals were killed by decapitation. Serum concentrations of gonadotrophins, testosterone and immunoactive inhibin as well as testicular concentrations of testosterone and bioactive inhibin were determined. Testicular histology was studied in Paraplast-embedded tissue stained with PAS and haematoxylin-eosin. Glycerol treatment caused a dose-dependent ablation of spermatogenesis in a distinct area around the site of injection. Serum concentrations of FSH increased proportionally with increasing spermatogenic damage while serum LH and testosterone remained unaltered except with the highest glycerol dose. The rise in serum FSH was significantly correlated with serum (r = -0.70, P less than 0.001) and testicular (r = -0.66, P less than 0.001) concentrations of inhibin. A less pronounced correlation was found between LH and serum inhibin (r = 0.48). No correlation was found between the ...Continue Reading

Citations

Aug 1, 1993·Cell and Tissue Research·M K VliegenE Nieschlag
Jun 26, 1995·Toxicology·A Thoreux-ManlayG Pinon-Lataillade
Dec 18, 2001·Animal Reproduction Science·J F Roser
Aug 2, 2012·Reproductive Biology·Neila MarouaniKhémais B Rhouma
Aug 9, 2006·Molecular and Cellular Endocrinology·Nicholas M RobertRobert S Viger
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Nov 24, 2006·Toxicology and Industrial Health·Naoufel ChamkhiaKhémais Ben Rhouma
Oct 19, 2002·The Prostate·Ping L ZhangGlenn Bubley

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