PMID: 9177171Jun 10, 1997Paper

Evidence for a mediator cycle at the initiation of transcription

Proceedings of the National Academy of Sciences of the United States of America
J Q SvejstrupR D Kornberg

Abstract

Free and elongating (DNA-bound) forms of RNA polymerase II were separated from yeast. Most cellular polymerase II was found in the elongating fraction, which contained all enzyme phosphorylated on the C-terminal domain and none of the 15-subunit mediator of transcriptional regulation. These and other findings suggest that mediator enters and leaves initiation complexes during every round of transcription, in a process that may be coupled to C-terminal domain phosphorylation.

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Citations

Apr 13, 1999·Journal of Cellular Physiology·L LaniaG Napolitano
Mar 17, 2004·Biochimica Et Biophysica Acta·Jesper Q Svejstrup
May 10, 2001·Current Opinion in Cell Biology·C Rachez, L P Freedman
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Jul 11, 2013·Chemical Reviews·Célia JeronimoFrançois Robert
Apr 9, 2013·Nature Structural & Molecular Biology·Kuang-Lei TsaiFrancisco J Asturias
Jun 12, 2013·Nature Structural & Molecular Biology·Odil Porrua, Domenico Libri
Feb 6, 2007·Nature Structural & Molecular Biology·Kevin Struhl
Jul 17, 2001·Molecular Microbiology·C M Gustafsson, T Samuelsson
Aug 22, 2013·Nucleic Acids Research·Thierry LacombeLaurent Kuras
Jun 29, 1999·Cold Spring Harbor Symposia on Quantitative Biology·R D Kornberg
Apr 10, 2003·Eukaryotic Cell·Denis Ostapenko, Mark J Solomon
Apr 1, 2003·Molecular and Cellular Biology·Mark J SwansonAlan G Hinnebusch
May 5, 2005·Molecular and Cellular Biology·Denis Ostapenko, Mark J Solomon
Apr 16, 2005·Molecular and Cellular Biology·Hongfang QiuAlan G Hinnebusch
Dec 20, 2008·PLoS Computational Biology·Agnes Tóth-PetróczyMonika Fuxreiter
Apr 8, 2014·Nature Structural & Molecular Biology·Célia Jeronimo, François Robert
Nov 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Laurent KurasRoger D Kornberg
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·D BalciunasS Björklund
Dec 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Daniel F TardiffMichael Rosbash
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Aug 4, 2006·Molecular Cell·Yuichiro TakagiRoger D Kornberg

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