Evidence for a non-precursor dopamine pool in noradrenergic neurones of the dog mesenteric artery

Naunyn-Schmiedeberg's Archives of Pharmacology
Patricio Soares-da-Silva

Abstract

The effects of dopamine beta-hydroxylase inhibition by disulfiram on dopamine and noradrenaline concentrations were investigated at various times in the main trunk and proximal branches of the dog mesenteric artery. The effects of desmethylimipramine and benztropine on the uptake of exogenous dopamine in the proximal branches of the mesenteric artery were also analyzed. The rate constant of dopamine accumulation after dopamine beta-hydroxylase inhibition in the main trunk (0.1137 h-1) was significantly higher than that observed in the proximal branches (0.075 h-1). The rate constants of noradrenaline decline were similar in both segments of the mesenteric artery (about 0.052 h-1). The uptake of exogenous dopamine in the proximal branches of the mesenteric artery was insensitive to benztropine and only blocked by desmethylimipramine. These results suggest the existence of a non-precursor dopamine pool in noradrenergic neurones supplying the proximal branches of the dog mesenteric artery, and also provide evidence in favour of the absence of independent dopaminergic neurones in this vascular area.

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Citations

Jan 1, 1992·Journal of Neural Transmission. General Section·R Favre-MauriceL Peyrin
Mar 26, 2004·Psychoneuroendocrinology·Fuad LechinAlex E Lechin
Jun 26, 1998·Journal of Cardiovascular Pharmacology·W C StanleyS S Hegde
Apr 1, 1993·Clinical and Experimental Pharmacology & Physiology·K OkadaA Nakase
Jul 25, 2014·European Journal of Pharmacology·Ana I LoureiroPatrício Soares-da-Silva
Jan 1, 1997·Clinical and Experimental Hypertension : CHE·M MannelliF Franchi
Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·M YoshimuraH Takahashi
Sep 1, 1988·British Journal of Pharmacology·P Soares-da-Silva
Jun 1, 1988·Journal of Autonomic Pharmacology·P Soares-da-Silva
Apr 10, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Nuno Miguel PiresPatrício Soares-da-Silva
Apr 29, 2015·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Ana I LoureiroPatrício Soares-da-Silva
Feb 3, 2015·European Journal of Pharmacology·Nuno Miguel PiresPatrício Soares-da-Silva
Feb 3, 2015·European Journal of Pharmacology·Maria João BonifácioPatrício Soares-da-Silva
Oct 10, 2014·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Bruno IgrejaPatrício Soares-da-Silva
Apr 15, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ines ArmandoPedro A Jose
Mar 2, 2019·Clinical and Experimental Hypertension : CHE·Diogo Nóbrega CatelasPatricio Soares-Da-Silva
Apr 8, 2020·ACS Pharmacology & Translational Science·Bruno IgrejaPatrício Soares-da-Silva

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