PMID: 8947494Nov 15, 1996Paper

Evidence for a novel cytoplasmic tRNA-protein complex containing the KH-multidomain protein vigilin

The Biochemical Journal
C KruseP K Müller

Abstract

Vigilin, a protein found predominantly in cells and tissues with a high biosynthetic capacity, was isolated in its native form from human HEp-2 cells (A.T.C.C. CCL23) by immunoaffinity chromatography. Vigilin forms part of a novel ribonucleoprotein complex that also contains additional, as yet uncharacterized, proteins. Experimental evidence suggests that the nucleic acids entrapped in this complex are protected from RNase and belong to the tRNA family. Using either a pool of total human RNA or radioactively labelled tRNA (tRNA (Asp**)) in rebinding experiments, we could show that tRNA is selectively recaptured by the RNA-depleted vigilin-containing complex.

Citations

Oct 4, 2005·FEBS Letters·Harsh H KaviJames A Birchler
Nov 3, 2010·Biochimica Et Biophysica Acta·Marta BatlleFernando Azorín
Jun 3, 2015·Cell Biology International·Ling WeiYang Qin
Dec 5, 2006·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Charli KruseThilo Wedel
Sep 27, 2016·Nature Communications·Mehrpouya B MobinMarkus Stoffel
Jan 22, 2014·Nucleic Acids Research·Wolf D HirschmannRalf-Peter Jansen
Jan 15, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·M MarcilJ Genest
Jun 25, 1998·Molecular and Cellular Biology·H KanamoriD J Shapiro
Apr 25, 2006·The Journal of Biological Chemistry·Francesc-Xavier MarsellachFernando Azorín
Aug 2, 2013·The Journal of Biological Chemistry·Isabel Cruz-GallardoIrene Díaz-Moreno
Oct 5, 2017·Wiley Interdisciplinary Reviews. RNA·Matthew Hk Cheng, Ralf-Peter Jansen
Aug 28, 2003·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Jyh-Yih ChenJen-Leih Wu
Apr 28, 2004·The International Journal of Biochemistry & Cell Biology·Tillman VollbrandtCharli Kruse
May 23, 2012·Proteome Science·Stephen Hsueh-Jeng LuPeter St George-Hyslop

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.