Evidence for a novel regulatory pathway activated by (carba)prostacyclin in preadipose and adipose cells

FEBS Letters
J AubertR Negrel

Abstract

Prostacyclin, one of the major prostanoids generated in adipose tissue, has been previously described as an autocrine/paracrine adipogenic effector, acting, in preadipose cells, by means of cAMP and free Ca2+ as cell surface receptor-mediated messengers. The present study presents evidence for the first time that its stable analogue, carbaprostacyclin, is unique among prostanoids in regulating the expression of two differentiation-dependent genes in preadipose and adipose cells in a way distinct from that elicited by its cell surface receptor. This regulation is likely mediated by some member(s) of the peroxisome proliferator-activated receptor family and suggests that prostacyclin behaves as an intracrine effector of adipose cell differentiation.

References

Dec 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R NégrelG Ailhaud
Jan 1, 1992·Annual Review of Nutrition·G AilhaudR Négrel
Feb 19, 1991·Biochimica Et Biophysica Acta·R M CataliotoR Negrel
Jan 15, 1989·The Biochemical Journal·R NégrelG Ailhaud
Jun 23, 1980·Biochimica Et Biophysica Acta·H E Claesson
Nov 12, 1982·Biochimica Et Biophysica Acta·B T HymanA A Spector
Feb 12, 1981·Biochemical and Biophysical Research Communications·R Négrel, G Ailhaud
Feb 1, 1981·Diabetes·L Axelrod, L Levine
Oct 13, 1995·The Journal of Biological Chemistry·K YuM A Lazar
May 15, 1994·Genes & Development·P TontonozB M Spiegelman
Apr 1, 1994·Molecular and Cellular Endocrinology·G G Kuiper, A O Brinkmann
Apr 15, 1996·Genes & Development·R P BrunB M Spiegelman

❮ Previous
Next ❯

Citations

Oct 8, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·G Ailhaud
Sep 2, 1999·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R Négrel
Apr 5, 2003·The International Journal of Biochemistry & Cell Biology·Stefan EngeliArya M Sharma
Feb 27, 2009·Journal of Lipid Research·Matthew W BuczynskiEdward A Dennis
Jan 19, 2016·Biochimica Et Biophysica Acta·Rayane A GhandourDidier F Pisani
Oct 15, 2013·The Journal of Nutritional Biochemistry·Maria E FrigoletArmando R Tovar
Jul 25, 1997·The Journal of Biological Chemistry·L FajasJ Auwerx
Jan 26, 2010·Nature Reviews. Endocrinology·Abishek IyerLindsay Brown
May 20, 2000·Annals of the New York Academy of Sciences·G PagèsJ S Saulnier-Blache
Jul 23, 1998·Physiological Reviews·F M GregoireH S Sul
May 23, 2002·American Journal of Hypertension·Gilberta GiacchettiFranco Mantero
Sep 23, 1997·Biochemical and Biophysical Research Communications·J AubertG Ailhaud
Nov 7, 2003·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·J Vane, R E Corin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.