Evidence for a novel subcortical mechanism for posterior cingulate cortex atrophy in HIV peripheral neuropathy.

Journal of Neurovirology
John R KeltnerCHARTER Group

Abstract

We previously reported that neuropathic pain was associated with smaller posterior cingulate cortical (PCC) volumes, suggesting that a smaller/dysfunctional PCC may contribute to development of pain via impaired mind wandering. A gap in our previous report was lack of evidence for a mechanism for the genesis of PCC atrophy in HIV peripheral neuropathy. Here we investigate if volumetric differences in the subcortex for those with neuropathic paresthesia may contribute to smaller PCC volumes, potentially through deafferentation of ascending white matter tracts resulting from peripheral nerve damage in HIV neuropathy. Since neuropathic pain and paresthesia are highly correlated, statistical decomposition was used to separate pain and paresthesia symptoms to determine which regions of brain atrophy are associated with both pain and paresthesia and which are associated separately with pain or paresthesia. HIV+ individuals (N = 233) with and without paresthesia in a multisite study underwent structural brain magnetic resonance imaging. Voxel-based morphometry and a segmentation/registration tool were used to investigate regional brain volume changes associated with paresthesia. Analysis of decomposed variables found that smaller midb...Continue Reading

References

Sep 1, 1988·Archives of Neurology·L R CaplanL S Adelman
Nov 1, 1984·Acta Neurologica Scandinavica·B MeldgaardH Sørensen
Sep 1, 1995·Stroke; a Journal of Cerebral Circulation·J S KimC S Chung
Dec 3, 1999·Stroke; a Journal of Cerebral Circulation·J S Kim, S Choi-Kwon
Feb 19, 2000·Muscle & Nerve·I MogyorosD Burke
Apr 11, 2001·Journal of the Peripheral Nervous System : JPNS·A Verma
Jul 17, 2001·Lancet·S E EatonS Tesfaye
Feb 26, 2003·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Catherine L CherrySteven L Wesselingh
Sep 1, 1953·Journal of Neurosurgery·C G DRAKE, K G MCKENZIE
Feb 26, 2004·Muscle & Nerve·David N HerrmannUNKNOWN North East AIDS Dementia (NEAD) Consortium
Oct 30, 2004·Journal of Clinical and Experimental Neuropsychology·Catherine L CareyUNKNOWN HNRC Group
Jan 22, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Daniel Bocchese NoraIrenio Gomes
Jun 7, 2005·Seminars in Neurology·J Robinson Singleton
Aug 20, 2005·Lancet Neurology·Justin C McArthurAvi Nath
Jan 10, 2006·Brain : a Journal of Neurology·Andrea E Cavanna, Michael R Trimble
Feb 8, 2006·AACN Clinical Issues·Susan G Dorsey, Patricia Gonce Morton
Jun 14, 2006·Neurology·D M SimpsonUNKNOWN ACTG A5117 Study Group
Nov 30, 2006·Diabetes Care·Dinesh SelvarajahSolomon Tesfaye
Jun 15, 2007·Neurology·L ZhouUNKNOWN NARC and ACTG A5117 Study Group
Jul 24, 2007·Progress in Neurobiology·X NavarroAntoni Valero-Cabré
Jul 4, 2008·PLoS Biology·Patric HagmannOlaf Sporns
Jul 11, 2008·Current Neuropharmacology·P MarchettiniC Marangoni
Jul 29, 2008·Neurologic Clinics·Alejandra Gonzalez-DuarteDavid M Simpson
Dec 11, 2008·Annals of Neurology·Ronald J EllisUNKNOWN CHARTER Group
Feb 21, 2009·PloS One·Franco CaudaSergio Canavero
Jun 3, 2009·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Lars GrøvleMargreth Grotle
Mar 26, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Richard C LennertzCheryl L Stucky
Jan 18, 2011·Brain Research·Amteshwar Singh Jaggi, Nirmal Singh
Feb 19, 2011·AIDS·Scott R EvansDavid B Clifford
May 21, 2011·The Journal of Pain : Official Journal of the American Pain Society·Lauren A WiebeKishore Shetty
Sep 13, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Francesco BrigoTommaso Bovi
Oct 25, 2011·PloS One·Marwan N BalikiA Vania Apkarian
Mar 20, 2012·Nature Neuroscience·Robert J ZatorreHeidi Johansen-Berg
Apr 4, 2012·Frontiers in Psychology·Adam G ThomasHeidi Johansen-Berg

❮ Previous
Next ❯

Citations

Feb 11, 2021·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Monica M DiazRonald J Ellis

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques
biopsies

Software Mentioned

FSL BET
FSL
FNIRT
FIRST
AFNI
- VBM

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nederlands tijdschrift voor geneeskunde
F M VAN DER HOEVEN
Der Internist
W Müller-Felber, D Pongratz
The Journal of the American Dental Association
Ira L Shapira
The Journal of the American Dental Association
Paul A Moore, Elliot V Hersh
The Journal of the American Dental Association
James S Dower
© 2022 Meta ULC. All rights reserved