Evidence for a peptidoglycan-like structure in Orientia tsutsugamushi

Molecular Microbiology
Sharanjeet AtwalJeanne Salje

Abstract

Bacterial cell walls are composed of the large cross-linked macromolecule peptidoglycan, which maintains cell shape and is responsible for resisting osmotic stresses. This is a highly conserved structure and the target of numerous antibiotics. Obligate intracellular bacteria are an unusual group of organisms that have evolved to replicate exclusively within the cytoplasm or vacuole of a eukaryotic cell. They tend to have reduced amounts of peptidoglycan, likely due to the fact that their growth and division takes place within an osmotically protected environment, and also due to a drive to reduce activation of the host immune response. Of the two major groups of obligate intracellular bacteria, the cell wall has been much more extensively studied in the Chlamydiales than the Rickettsiales. Here, we present the first detailed analysis of the cell envelope of an important but neglected member of the Rickettsiales, Orientia tsutsugamushi. This bacterium was previously reported to completely lack peptidoglycan, but here we present evidence supporting the existence of a peptidoglycan-like structure in Orientia, as well as an outer membrane containing a network of cross-linked proteins, which together confer cell envelope stability. ...Continue Reading

References

May 1, 1991·European Journal of Epidemiology·A TamuraN Ohashi
Aug 1, 1982·The Journal of Infectious Diseases·C L WissemanD T Brown
Aug 16, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·C G MoronD H Walker
Sep 23, 2003·Current Opinion in Infectious Diseases·George Watt, Philippe Parola
Jan 18, 2006·Trends in Microbiology·Andrea J McCoy, Anthony T Maurelli
Feb 24, 2006·Emerging Infectious Diseases·Simaly PhongmanyPaul N Newton
Feb 25, 2006·Cell·Javier Pizarro-Cerdá, Pascale Cossart
May 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Nam-Hyuk ChoIk-Sang Kim
Jul 31, 2007·Biochimica Et Biophysica Acta·Waldemar Vollmer, Ute Bertsche
Jan 16, 2008·FEMS Microbiology Reviews·Waldemar VollmerMiguel A de Pedro
May 30, 2008·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Keisuke NakayamaTetsuya Hayashi
Dec 17, 2009·International Journal of Medical Microbiology : IJMM·Tanja Schneider, Hans-Georg Sahl
Feb 27, 2010·Proteomics·Bon-A ChoIk-Sang Kim
May 18, 2010·Microbial Pathogenesis·Kyung-Ah ChoSo-Youn Woo
Dec 18, 2012·ACS Chemical Biology·M Sloan SiegristCarolyn R Bertozzi
Mar 23, 2013·International Journal of Medical Microbiology : IJMM·Jennifer VollmerKenneth Pfarr
May 3, 2013·Cold Spring Harbor Perspectives in Medicine·Robert J BastidasRaphael H Valdivia
Aug 13, 2013·PLoS Neglected Tropical Diseases·Maria Rosario CapedingTram Anh Wartel
Dec 3, 2013·Nature Communications·Martin PilhoferGrant J Jensen
Jan 11, 2014·Molecular Microbiology·Robert D TurnerSimon J Foster
Mar 13, 2014·Frontiers in Cellular and Infection Microbiology·Stefania De BenedettiBeate Henrichfreise
Apr 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Peyton ShiehCarolyn R Bertozzi
Apr 22, 2014·The Lancet Global Health·Mayfong MayxayPaul N Newton
May 31, 2014·PloS One·Eric SauvagePaulette Charlier
Jun 4, 2014·Chembiochem : a European Journal of Chemical Biology·Tamimount Mohammadi, Eefjan Breukink
Aug 15, 2014·PLoS Neglected Tropical Diseases·Christian A KellerBernhard Fleischer
Jan 7, 2015·Nature·Losee L LingKim Lewis

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Citations

Feb 2, 2018·Clinical Microbiology Reviews·Fabián E DíazAlexis M Kalergis
Oct 2, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tri WangrangsimakulNicholas P J Day
Nov 28, 2017·Molecular Microbiology·Christian OttenJeanne Salje
Feb 13, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lynn Soong
Dec 19, 2020·International Journal of Medical Microbiology : IJMM·Anwesha Banerjee, Smita Kulkarni
Aug 12, 2020·Trends in Microbiology·Jantana WongsantichonJeanne Salje
Jun 11, 2021·Expert Review of Anti-infective Therapy·Chin-Te LuPo-Ren Hsueh

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