Evidence for a physiological role of angiotensin-(1-7) in the control of hydroelectrolyte balance

Hypertension
R A SantosN C Baracho

Abstract

In this study we evaluated the possibility that angiotensin-(1-7) [Ang-(1-7)] acts as an endogenous osmoregulatory peptide by determining the effect of acute administration of its selective antagonist [D-Ala7]Ang-(1-7) (A-779) on renal function parameters in rats. In addition, we investigated the physiological mechanisms involved in the antidiuretic effect of Ang-(1-7). The antidiuretic effect of Ang-(1-7) (40 pmol/0.05 mL per 100 g BW) in water-loaded rats was completely blocked by A-779 (vehicle-treated, 3.34 +/- 0.43 mL/h; Ang-(1-7), 1.48 +/- 0.23; A-779, 2.72 +/- 0.35; Ang-(1-7) plus A-779, 3.26 +/- 0.49). In contrast, the antidiuretic effect of Ang-(1-7) was not significantly changed by a vasopressin V2 receptor antagonist in a dose that completely blocked the antidiuresis produced by an equipotent dose of vasopressin. In addition, Ang-(1-7) administration did not significantly change vasopressin plasma levels in water-loaded rats. The antidiuretic effect of Ang-(1-7) in water-loaded rats was associated with a reduction of creatinine clearance (0.68 +/- 0.04 versus 1.38 +/- 0.32 mL/min in vehicle-treated rats, P <.05) and an increase in urine osmolality (266.8 +/- 32.7 versus 182.8 +/- 14 mOsm/kg in vehicle-treated rats, P...Continue Reading

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Citations

Sep 29, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ana Cristina Simões E Silva, Joseph T Flynn
Jun 2, 2005·Regulatory Peptides·L S LaraC Caruso-Neves
Jan 8, 1999·Regulatory Peptides·C M Ferrario, S N Iyer
Mar 18, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Rui YangAlain G Dupont
Jan 27, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Florian GembardtThomas Walther
Aug 19, 2007·Journal of Cardiovascular Pharmacology·Mohan K Raizada, Anderson J Ferreira
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Mar 1, 2008·Clinical and Experimental Pharmacology & Physiology·A KoitkaC Tikellis
Apr 9, 2010·American Journal of Physiology. Renal Physiology·Carlos M Ferrario, Jasmina Varagic
Jan 7, 2009·Therapeutic Advances in Cardiovascular Disease·Lauren Anton, K Bridget Brosnihan
Oct 25, 2012·The Journal of Endocrinology·Robson A S SantosMichael Bader
Aug 6, 2008·World Journal of Gastroenterology : WJG·Regina M PereiraAna Cristina Simoes e Silva
Dec 17, 2009·Neurological Research·Ronen R LekerJosé E Cohen
Oct 2, 2008·Neurological Research·Alexander Y ZubkovAlejandro A Rabinstein
Jun 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Robson A S SantosThomas Walther
Apr 21, 2012·International Journal of Hypertension·Sergio Veloso Brant Pinheiro, Ana Cristina Simões E Silva
Jan 4, 1998·Kidney International·R Ardaillou, D Chansel
Feb 10, 2009·Journal of the American Society of Hypertension : JASH·J JoynerKb Brosnihan
Jun 24, 2008·European Journal of Pharmacology·Linda EbermannThomas Walther
Dec 26, 2006·Journal of Hepatology·Regina Maria PereiraAna Cristina Simões e Silva
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Jun 10, 2010·Clinical Science·Kátia D da SilveiraMaria A Ribeiro Vieira
Jun 2, 2012·European Journal of Pharmacology·Silvia Heringer-WaltherThomas Walther
Jul 27, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C Caruso-NevesA G Lopes
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