PMID: 2485094Jan 1, 1989Paper

Evidence for a potential common T-cell epitope between human thyroid peroxidase and human thyroglobulin with implications for the pathogenesis of autoimmune thyroid disease

Autoimmunity
S M McLachlan, B Rapoport

Abstract

In order to explore the possibility that, in autoimmune thyroid disease, anti-thyroglobulin (Tg) and anti-thyroid peroxidase (TPO) antibodies arise concurrently because they share a common T-cell epitope, we performed a detailed comparative analysis of the cDNA nucleotide sequences corresponding to these two genes. We discovered an 8 amino acid region (Leu-Ser-Glu-Asp-Leu-Leu-Ser- Ile in human TPO) in which there were 6 identical and 2 conserved amino acid residues when compared with human Tg. This remarkably similar region is near the amino-terminus of human TPO (residues 119-126) and the carboxyl-terminus of human Tg (residues 2763-2770). A second feature of interest was that this region of homology conforms to the Rothbard algorithm for a T-cell epitope. Third, probing of the Swiss-protein data bank (10,008 proteins containing 2,952,765 amino acids) with the human TPO region revealed greater homology for human Tg than for any other eukaryotic protein. Two bacterial proteins (E. coli aminopeptidase N and stringent starvation protein) had higher homology scores from human TPO than did human Tg. Our findings provide circumstantial evidence that human TPO and human Tg, and possibly certain bacterial proteins, do indeed share com...Continue Reading

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Citations

Aug 1, 1996·Journal of Neurology·I Kothbauer-MargreiterC W Hess
Aug 17, 2004·Thyroid : Official Journal of the American Thyroid Association·Sandra M McLachlan, Basil Rapoport
Jan 27, 1999·Thyroid : Official Journal of the American Thyroid Association·J TakamatsuT Hosoya
Jan 27, 2005·Thyroid : Official Journal of the American Thyroid Association·Salvatore BenvengaFrancesco Trimarchi
Mar 31, 2006·Thyroid : Official Journal of the American Thyroid Association·Salvatore BenvengaFabrizio Guarneri
Sep 8, 2007·Thyroid : Official Journal of the American Thyroid Association·Sandra M McLachlan, Basil Rapoport
Oct 1, 1993·Journal of Internal Medicine·S M McLachlan, B Rapoport
Nov 15, 2008·Annual Review of Immunology·Marc Feldmann
Dec 31, 1997·Journal of Endocrinological Investigation·S BenvengaF Trimarchi
Dec 29, 2000·International Reviews of Immunology·S M McLachlan, B Rapoport
Jan 1, 1990·Autoimmunity·B E WenzelJ Heesemann
Aug 16, 2005·Archives of Biochemistry and Biophysics·Jean Ruf, Pierre Carayon
Oct 5, 2013·Endocrine Reviews·Sandra M McLachlan, Basil Rapoport
Jan 10, 2003·The Journal of Clinical Endocrinology and Metabolism·Francesco LatrofaSandra M McLachlan
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Sep 4, 1999·Journal of Endocrinological Investigation·S BenvengaA Facchiano
Nov 1, 1990·Clinical and Experimental Immunology·N FukumaB Rees Smith

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