Evidence for a probable causal relationship between tretinoin, acitretin, and etretinate and intracranial hypertension

Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society
Frederick W Fraunfelder, Frederick W Fraunfelder

Abstract

With the recognition that vitamin A and isotretinoin may cause intracranial hypertension, the authors reviewed 331 case reports of ocular side effects associated with the three other marketed retinoids: tretinoin, acitretin, and etretinate. The reports were drawn from the National Registry of Drug-Induced Ocular Side Effects, the World Health Organization (WHO), the Food and Drug Administration, and medical journals between 1979 and 2003. There were 21 cases of intracranial hypertension associated with these three retinoids, leading to an inference that they are probably causally related to intracranial hypertension by WHO criteria. The lack of positive rechallenge data precludes the inference of a definite causal relationship to intracranial hypertension by WHO criteria. The inference of an independent causal role of these retinoids is further cautioned by the fact that six patients were concurrently using tetracycline or minocycline. Even so, the data suggest that all retinoids may, in rare instances, cause intracranial hypertension.

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Citations

Nov 21, 2012·Expert Opinion on Drug Safety·Shivani V TripathiSteven R Feldman
Jul 16, 2008·Expert Opinion on Drug Metabolism & Toxicology·Mei-Lin PangJohn Koo
Dec 27, 2015·The American Journal of Medicine·Christopher Keith OldroydKrishna Dani
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Jan 11, 2007·Drugs·Ricardo M Santaella, Frederick W Fraunfelder
Jun 20, 2008·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Syndee J Givre, David Fleischman
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Jun 6, 2008·Southern Medical Journal·Josef Finsterer
Jul 14, 2012·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·James Corbett

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