PMID: 6412233Sep 1, 1983Paper

Evidence for a proenkephalin-like precursor in amphibian brain

Proceedings of the National Academy of Sciences of the United States of America
D L KilpatrickS Udenfriend

Abstract

The mammalian proenkephalin-derived peptides [Leu]enkephalin, [Met]enkephalin, and [Met]enkephalin-Arg6-Phe7 were identified in acid extracts of the brain of Bufo marinus by using reversed-phase HPLC and specific radioimmunoassays. [Met]Enkephalin was the predominant opioid peptide present (270 pmol/g). In contrast, the octapeptide [Met]enkephalin-Arg6-Gly7-Leu8, which is also derived from mammalian proenkephalin, was not detected. The ratio of free [Met]enkephalin to [Met]enkephalin-Arg6-Phe7 was found to be 3.5 to 1, which is similar to that observed in mammalian proenkephalin-containing tissues. Together these data (i) indicate that amphibian brain contains a proenkephalin related to the mammalian precursor and (ii) establish the existence of enkephalins and proenkephalin-derived enkephalin-containing peptides in a submammalian species.

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Citations

Jan 1, 1989·Pharmacology & Therapeutics·S Nilsson, S Holmgren
Jan 1, 1985·Peptides·G MarinoA Miralto
Jan 1, 1984·Neurochemistry International·F LeboulengerH Vaudry
Apr 16, 2003·Hormones and Behavior·E BujdosóG Telegdy
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·D L KilpatrickS Udenfriend
Jan 21, 2003·Mass Spectrometry Reviews·Robert M DoresPhillip B Danielson
Mar 1, 1989·The Journal of Comparative Neurology·I MerchenthalerJ L Maderdrut
Jan 3, 2012·General and Comparative Endocrinology·Leanne K KomorowskiRobert M Dores
May 18, 2010·Journal of Peptide Science : an Official Publication of the European Peptide Society·Yuliia N NekrasovaElena V Navolotskaya
Jan 1, 1992·General and Comparative Endocrinology·M PestarinoF Facchinetti
Feb 15, 1986·Archives of Biochemistry and Biophysics·I Lindberg, L White
Sep 24, 2004·Regulatory Peptides·Fanni TóthSándor Benyhe
Mar 20, 1999·General and Comparative Endocrinology·P B Danielson, R M Dores
May 15, 1992·The Journal of Comparative Neurology·A Reiner, R G Northcutt
Feb 15, 1987·The Journal of Comparative Neurology·A Reiner, R G Northcutt
Feb 15, 1989·The Journal of Comparative Neurology·A ReinerR Quirion

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