Evidence for a profound remodeling of skeletal muscle and its microvasculature in sickle cell anemia

The American Journal of Pathology
Marion RavelojaonaLaurent Messonnier

Abstract

Sickle cell anemia (SCA) is a hemoglobinopathy leading to major hematologic, hemorheologic, and hemodynamic disorders that induce various complications, including organ failure, and ultimately lead to death. Here, we assessed for the first time repercussions of SCA on skeletal muscle and its microvasculature. Twenty-seven sedentary Cameroonian volunteer men participated in the study. They were assigned to one of three groups according to their hemoglobin status (healthy control subjects, n = 10; sickle cell trait carriers, n = 10; and SCA patients, n = 7) and underwent muscle biopsy of the vastus lateralis. SCA was associated with microvessel rarefaction, decrease in capillary tortuosity, and widening of microvessel diameter. The absence of capillary wall reinforcement was shown by lack of wall thickening and lack of fibrous tissue or smooth muscle in their constitution. We also observed changes in fiber type distribution, muscle atrophy, an increase in satellite cell number, and a decrease in activity of creatine kinase and several oxidative enzymes. No signs of tissue necrosis, inflammatory stress, fibrosis, or segmented fibers were observed. The present study highlighted marked effects of SCA on microvascular, structural, an...Continue Reading

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Citations

Sep 8, 2017·British Journal of Haematology·Vandana SachdevJonathan R Lindner
Apr 6, 2018·Journal of Pediatric Hematology/oncology·Kelly A DoughertyVirginia A Stallings
Jul 17, 2018·Somatosensory & Motor Research·Priscila Oliveira SilvaAgnaldo José Lopes
Mar 29, 2019·Medicine and Science in Sports and Exercise·Laurent A MessonnierLéonard Féasson
Nov 26, 2019·Journal of Pediatric Hematology/oncology·Jefferson N BrownellVirginia A Stallings
Jul 19, 2020·American Journal of Hematology·Angèle N MerletUNKNOWN EXDRE collaborative study group
Jul 30, 2018·Journal of Back and Musculoskeletal Rehabilitation·Carlos Eduardo Amaral GonçalvesAgnaldo José Lopes
Aug 21, 2019·Oxidative Medicine and Cellular Longevity·Etienne GouraudCamille Faes
Dec 4, 2020·Journal of Applied Physiology·Laurent A MessonnierLéonard Féasson
Aug 11, 2018·Medicine and Science in Sports and Exercise·Angèle N MerletLaurent A Messonnier
May 24, 2021·European Journal of Applied Physiology·Etienne GouraudChristophe Hautier
Aug 15, 2021·European Journal of Clinical Investigation·Nadjib HammoudiStéphane N Hatem

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