PMID: 8987400Nov 1, 1996Paper

Evidence for a Ras/Ral signaling cascade

Trends in Biochemical Sciences
L A FeigS Cantor

Abstract

It is becoming clear that Ras proteins mediate their diverse biological functions by binding to, and participating in, the activation of multiple downstream targets. Recent work has identified nucleotide-exchange factors for Ral-GTPases as the newest members of the set of putative Ras 'effector molecules'. This new work has also detected two potential downstream targets of Ral proteins, a novel CDC42/Rac GTPase-activating protein and a phospholipase D.

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