Evidence for a role of D1 dopamine receptors in d-amphetamine's effect on timing behaviour in the free-operant psychophysical procedure

Psychopharmacology
T H C CheungE Szabadi

Abstract

Temporal differentiation of operant behaviour is sensitive to dopaminergic manipulations. Studies using the fixed-interval peak procedure implicated D2 dopamine receptors in these effects. Less is known about the effects of dopaminergic manipulations on temporal differentiation in other timing schedules. To examine the effects of a D1 antagonist,8-bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol (SKF-83566), and a D2 antagonist, haloperidol, on performance on the free-operant psychophysical procedure, and the ability of these antagonists to reverse the effects of the catecholamine-releasing agent, d-amphetamine on performance. The antagonists' ability to reverse d-amphetamine-induced hyperlocomotion was also examined. Rats responded on two levers (A and B) under a free-operant psychophysical schedule, in which reinforcement was provided intermittently for responding on A during the first half, and B during the second half, of 50-s trials. Logistic functions were fitted to the relative response rate data (percent responding on B [%B] vs time [t]) in each treatment condition, and quantitative timing indices [T50 (value of t corresponding to %B=50) and Weber fraction] were compared among treatments. Effects of the t...Continue Reading

References

Nov 1, 1975·European Journal of Pharmacology·M RaiteriG Levi
Apr 1, 1988·Psychological Review·P R Killeen, J G Fetterman
Jul 1, 1987·Pharmacology, Biochemistry, and Behavior·D A EckermanG S Breese
May 1, 1968·Journal of the Experimental Analysis of Behavior·A C Catania, G S Reynolds
Dec 16, 1982·Brain Research·C SpyrakiA G Phillips
Mar 1, 1980·Journal of the Experimental Analysis of Behavior·D A Stubbs
Jan 1, 1995·Psychopharmacology·D N Velázquez MartínezJ E Villarreal
Jul 1, 1994·Trends in Pharmacological Sciences·P Seeman, H H Van Tol
Apr 1, 1996·Pharmacology, Biochemistry, and Behavior·D L Frederick, J D Allen
Jun 1, 1996·Brain Research. Cognitive Brain Research·W H Meck
Apr 1, 1997·Current Opinion in Neurobiology·J GibbonC Gallistel
Sep 23, 1997·Pharmacology, Biochemistry, and Behavior·P J KraemerR W Brown
Apr 29, 1998·Psychopharmacology·P J BayleyG R Dawson
Dec 2, 1998·Behavioural Pharmacology·F M Herrera, D N Velazquez Martinez
Jul 25, 2000·Psychopharmacology·T J ChiangE Szabadi
Aug 31, 2000·Journal of the Experimental Analysis of Behavior·A Machado, P Guilhardi
Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·M-Y HoE Szabadi
May 9, 2002·Behavioral Neuroscience·Catalin V Buhusi, Warren H Meck
Sep 10, 2002·Journal of the Experimental Analysis of Behavior·Amy L OdumDavid W Schaai
May 22, 2003·Pharmacology, Biochemistry, and Behavior·Michael R DrewPeter D Balsam
Feb 26, 2004·Behavioral Neuroscience·Matthew S MatellWarren H Meck
Oct 7, 2004·Brain Research. Cognitive Brain Research·Matthew S Matell, Warren H Meck
Nov 24, 2004·Neuroscience and Biobehavioral Reviews·Christopher J MacDonald, Warren H Meck
Aug 10, 2005·Proceedings of the National Academy of Sciences of the United States of America·Martin Lévesque, André Parent
Jul 1, 1976·Journal of the Experimental Analysis of Behavior·D A Stubbs
Jan 1, 1994·Journal of the Experimental Analysis of Behavior·L A Bizo, K G White

❮ Previous
Next ❯

Citations

Apr 18, 2013·PLoS Computational Biology·Dominic StandageMichael C Dorris
Feb 4, 2012·Behavioural Brain Research·L Valencia-TorresE Szabadi
Nov 24, 2007·Alcoholism, Clinical and Experimental Research·Warren H Meck
Mar 3, 2021·Neuroscience and Biobehavioral Reviews·Bowen J FungMarshall G Hussain Shuler
May 21, 2021·Scientific Reports·Yusuf S AlthobaitiZahoor A Shah

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here