Evidence for a role of developmental genes in the origin of obesity and body fat distribution.

Proceedings of the National Academy of Sciences of the United States of America
Stephane GestaC Ronald Kahn

Abstract

Obesity, especially central obesity, is a hereditable trait associated with a high risk for development of diabetes and metabolic disorders. Combined gene expression analysis of adipocyte- and preadipocyte-containing fractions from intraabdominal and subcutaneous adipose tissue of mice revealed coordinated depot-specific differences in expression of multiple genes involved in embryonic development and pattern specification. These differences were intrinsic and persisted during in vitro culture and differentiation. Similar depot-specific differences in expression of developmental genes were observed in human subcutaneous versus visceral adipose tissue. Furthermore, in humans, several genes exhibited changes in expression that correlated closely with body mass index and/or waist/hip ratio. Together, these data suggest that genetically programmed developmental differences in adipocytes and their precursors in different regions of the body play an important role in obesity, body fat distribution, and potential functional differences between internal and subcutaneous adipose tissue.

References

Jul 1, 1976·Clinics in Endocrinology and Metabolism·J Hirsch, B Batchelor
Sep 1, 1970·Archives of Dermatology·W B Shelley, A K Izumi
Jun 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·F A PereiraS Y Tsai
Oct 1, 1994·Physiological Reviews·A H Kissebah, G R Krakower
Jan 1, 1994·Aesthetic Plastic Surgery·R A ErsekA V Salisbury
Nov 1, 1993·European Journal of Clinical Investigation·P MauriègeP J Lupien
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·R J BlaschkeG A Rappold
Jan 27, 1999·The Journal of Clinical Endocrinology and Metabolism·A GargJ L Fleckenstein
Feb 2, 2000·Nature Genetics·S ShackletonR C Trembath
May 16, 2000·Twin Research : the Official Journal of the International Society for Twin Studies·T L NelsonT P Miles
Mar 13, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M WabitschH Hauner
Apr 9, 2001·Seminars in Cell & Developmental Biology·B De Cat, G David
Dec 1, 2001·Reviews in Endocrine & Metabolic Disorders·Q Tong, G S Hotamisligil
Dec 4, 2001·Annals of Medicine·H Koutnikova, J Auwerx
Dec 18, 2001·Experimental Biology and Medicine·F M Gregoire
Apr 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tamara TchkoniaJames L Kirkland
Mar 28, 2003·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·G AtzmonN Barzilai
Jul 16, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·V van HarmelenH Hauner
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·H Weiler, B H Isermann
Oct 18, 2003·Journal of Lipid Research·Kristina LinderGunnar Norstedt
Jan 23, 2004·PLoS Biology·Sophie I CandilleGregory S Barsh
May 8, 2004·The Journal of Biological Chemistry·Matthias BlüherC Ronald Kahn
May 26, 2004·Endocrinology and Metabolism Clinics of North America·Abhimanyu Garg, Anoop Misra
Sep 2, 2004·Obesity Research·Marie-Claude VohlAndré Tchernof
Sep 24, 2004·American Journal of Physiology. Endocrinology and Metabolism·Tamara TchkoniaJames L Kirkland
Jan 18, 2005·Mechanisms of Development·Manvendra K SinghAndreas Kispert
Jan 22, 2005·Annals of the New York Academy of Sciences·Finn Edler von EybenUNKNOWN Abdominal Obesity Study Group
Feb 3, 2005·The Journal of Endocrinology·Katie WynneSteve Bloom
May 10, 2005·The Proceedings of the Nutrition Society·Daniel Ricquier
Jun 10, 2005·Development·Jacqueline Deschamps, Johan van Nes

❮ Previous
Next ❯

Citations

Nov 15, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Danielle R ReedAlexander A Bachmanov
May 9, 2009·European Journal of Applied Physiology·José C Rosa NetoMarília Seelaender
Jul 28, 2007·Reviews in Endocrine & Metabolic Disorders·Felix Grün, Bruce Blumberg
Jan 19, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Flora IppolitiRita Businaro
Jan 11, 2013·Expert Reviews in Molecular Medicine·Angelo CignarelliFrancesco Giorgino
Dec 15, 2010·The Proceedings of the Nutrition Society·Katherine E Pinnick, Fredrik Karpe
Jun 15, 2007·Cell Research·Silvia I Anghel, Walter Wahli
May 15, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·D SchleinitzP Kovacs
Mar 3, 2010·Nature Reviews. Endocrinology·Thien T Tran, C Ronald Kahn
Oct 23, 2013·Nature Reviews. Endocrinology·Alexander Bartelt, Joerg Heeren
Oct 15, 2008·Nature Reviews. Genetics·Aldons J LusisKaren Reue
Dec 2, 2006·Nature Reviews. Molecular Cell Biology·Evan D Rosen, Ormond A MacDougald
Sep 29, 2011·Nature Reviews. Molecular Cell Biology·Ana G Cristancho, Mitchell A Lazar
Apr 25, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C-H WuD Gallagher
Feb 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Stephane GestaC Ronald Kahn
Jun 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Kevin Y LeeC Ronald Kahn
Apr 7, 2007·Omics : a Journal of Integrative Biology·Guang Sun
Jul 26, 2008·Molecular Biology of the Cell·Carlos PantojaKeith R Yamamoto
Jan 29, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Mark J CartwrightJames L Kirkland
Nov 17, 2009·Current Opinion in Lipidology·Matthias Blüher
Feb 8, 2013·Genes & Development·Jun WuBruce M Spiegelman
Dec 8, 2009·Science·Howard Y Chang
May 26, 2010·Molecular and Cellular Biology·C F ZizolaS Vogel
Sep 8, 2006·Gut·Laurent Peyrin-BirouletPierre Desreumaux
Apr 27, 2010·Annual Review of Nutrition·Mark P Keller, Alan D Attie
Jun 24, 2010·American Journal of Physiology. Endocrinology and Metabolism·Oleg VarlamovCharles T Roberts
Jan 30, 2010·Gerontology·Anna SepeJames L Kirkland
Jan 6, 2009·Circulation Research·Tapan K ChatterjeeNeal L Weintraub
Dec 3, 2010·The Journal of Clinical Investigation·Patrick SealeBruce M Spiegelman
Oct 6, 2010·Lipids in Health and Disease·Fábio S LiraRonaldo V T Santos
Nov 3, 2010·Lipids in Health and Disease·José C Rosa NetoMarco T de Mello
Sep 26, 2007·Head & Face Medicine·Paul Svedman
Jun 2, 2012·Biology of Sex Differences·Kalypso KarastergiouSusan K Fried
Dec 6, 2011·Journal of Lipid Research·William P CawthornOrmond A MacDougald
Nov 15, 2012·The Journal of Clinical Endocrinology and Metabolism·Kalypso KarastergiouSteven R Smith

❮ Previous
Next ❯

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