Evidence for a role of early oestrogens in the central processing of sexually relevant olfactory cues in female mice.

The European Journal of Neuroscience
Sylvie PiermanJulie Bakker

Abstract

We previously found that female aromatase knockout (ArKO) mice showed less investigation of socially relevant odours as well as reduced sexual behaviour. We now ask whether these behavioural deficits might be due to an inadequate processing of odours in female ArKO mice. Therefore, we exposed female ArKO mice to same- and opposite-sex urinary odours and determined the expression of the immediate early gene c-Fos along the main and accessory olfactory projection pathways. We included ArKO males in the present study as we previously observed that they show female-typical detection thresholds of urinary odours, suggesting a role for perinatal oestrogens in these behavioural responses. No sex or genotype differences were observed in the olfactory bulb after urine exposure. By contrast, sex differences in c-Fos responses were observed in wild-type (WT) mice following exposure to male urine in the more central regions of the olfactory pathway; only WT females showed a significant Fos induction in the amygdala, central medial pre-optic area and ventromedial hypothalamus. However, ArKO females did not show a c-Fos response to male odours in the ventromedial hypothalamus, suggesting that the processing of male odours is affected in ArKO...Continue Reading

References

Dec 1, 1973·Physiology & Behavior·D A Edwards, K G Burge
Jun 1, 1972·Physiology & Behavior·M L Thompson, D A Edwards
Sep 1, 1969·Brain Research·D W Pfaff, C Pfaffmann
Feb 1, 1995·Physiology & Behavior·K M DorriesB P Halpern
Jan 1, 1997·Brain Research Bulletin·A Guillamón, S Segovia
Nov 25, 1998·Biochemical and Biophysical Research Communications·S HondaS Maeda
Oct 26, 1999·Science·E B Keverne
Sep 15, 2001·Nature·S Firestein
Oct 9, 2002·Hormones and Behavior·J BakkerJ Balthazart
Jan 20, 2006·The European Journal of Neuroscience·Matthieu KellerJulie Bakker
Feb 2, 2006·Hormones and Behavior·Daniel W WessonJulie Bakker
Apr 11, 2007·The European Journal of Neuroscience·Cristian Bodo, Emilie F Rissman

❮ Previous
Next ❯

Citations

Dec 15, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alexandra Veyrac, Julie Bakker
Aug 6, 2013·Frontiers in Neuroendocrinology·Aras Petrulis
Jul 23, 2013·Frontiers in Neuroendocrinology·Michael J Baum, Julie Bakker
May 12, 2010·Frontiers in Neuroendocrinology·P J BonthuisE F Rissman
Apr 3, 2013·Hormones and Behavior·Aras Petrulis
Nov 15, 2011·Physiology & Behavior·Amy E Clipperton-AllenElena Choleris
Jul 22, 2008·Nature Neuroscience·Che SergueraLiliana Minichiello
Jul 22, 2020·Endocrinology·Morgan E Hernandez ScudderAndrea C Gore
Jul 1, 2015·Hormones and Behavior·Kelsy S J ErvinElena Choleris
Dec 24, 2018·Hormones and Behavior·Ashlyn Swift-Gallant

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.