PMID: 6409355Jun 27, 1983Paper

Evidence for a role of endogenous opioids in the nigrostriatal system: influence of naloxone and morphine on nigrostriatal dopaminergic supersensitivity

Brain Research
I D HirschhornM H Makman

Abstract

The effects of morphine and naloxone on nigrostriatal function were evaluated by their influence on rotational behavior in rats with unilateral lesions of the substantial nigra. Two different rotational syndromes which result from different lesion placements, were examined. Rats with the contraversive syndrome, when given apomorphine, rotate away from the lesioned side, while rats with the ipsiversive syndrome rotate toward the lesioned side. In both syndromes, rats rotate toward the lesioned side when given amphetamine. Morphine or naloxone, alone, was without effect in either syndrome. Morphine antagonized rotation by either apomorphine or amphetamine in both syndromes. Naloxone stimulated apomorphine-induced rotation in contraversive rats and antagonized amphetamine-induced rotation in ipsiversive rats. These findings support a functional role of endogenous opioids in this dopaminergic system. The effects of morphine and naloxone on apomorphine-induced rotation indicate that opiates act at a postsynaptic site in this system. Finally, the different responses to naloxone and morphine in the two rotational syndromes suggest that an enkephalinergic asymmetry may underlie the differences in behavioral responses between these two ...Continue Reading

References

Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·U Ungerstedt
Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R K MishraM H Makman
Jun 1, 1973·Journal of Pharmaceutical Sciences·W M Davis, C C Brister
Aug 8, 1980·European Journal of Pharmacology·T F SeegerE L Gardner
Dec 1, 1959·The Journal of Comparative Neurology· de GROOT

❮ Previous
Next ❯

Citations

Dec 1, 1984·Italian Journal of Neurological Sciences·A Albanese, M C Altavista
Nov 1, 1991·Pharmacology, Biochemistry, and Behavior·E L Gardner, J H Lowinson
Jan 1, 1984·Progress in Neuro-psychopharmacology & Biological Psychiatry·M R Peterson, H A Robertson
Jan 1, 1984·General Pharmacology·V V PetkovE Konstantinova
Jan 1, 1995·Brain Research Bulletin·N L Ostrowski, A Pert
Jul 1, 1988·Journal of Neurosurgery·M S FiandacaD M Gash
Mar 11, 2008·Behavioural Brain Research·Claudio Da CunhaNewton Sabino Canteras
Jan 1, 1987·Neuroscience and Biobehavioral Reviews·J G Pfaus, B B Gorzalka
Mar 1, 1987·Circulation Research·J A Bevan, J E Brayden

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.