Evidence for a role of heat shock factor 1 in inhibition of NF-kappaB pathway during heat shock response-mediated lung protection

American Journal of Physiology. Lung Cellular and Molecular Physiology
Delphine WirthP Gustin

Abstract

Heat shock transcription factor (HSF)-1 is recognized as a central component of the heat shock response, which protects against various harmful conditions. However, the mechanisms underlying the protection and the role of HSF-1 in these mechanisms have not yet been clearly elucidated. Using HSF-1 knockout mice (Hsf1(-/-)), we examined whether heat shock response-mediated lung protection involved an inhibition of the proinflammatory pathway via an interaction between HSF-1 and NF-kappaB, in response to cadmium insult. The HSF-1-dependent protective effect against intranasal instillation of cadmium (10 and 100 microg/mouse) was demonstrated by the higher protein content (1.2- and 1.4-fold), macrophage (1.6- and 1.9-fold), and neutrophil (2.6- and 1.8-fold) number in bronchoalveolar fluids, higher lung wet-to-dry weight ratio, and more severe lung damage evaluated by histopathology in Hsf1(-/-) compared with wild-type animals. These responses were associated with higher granulocyte/macrophage colony-stimulating factor (GM-CSF; 1.7-fold) but not TNF-alpha concentrations in bronchoalveolar fluids of Hsf1(-/-) mice compared with those of wild-type animals, indicating that HSF-1 behaved as a repressor of specific cytokine production i...Continue Reading

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Oct 14, 2003·Toxicology and Applied Pharmacology·Delphine WirthPascal Gustin

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Citations

May 31, 2008·Journal of the Association for Research in Otolaryngology : JARO·Mona TalebLisa L Cunningham
May 23, 2012·Proceedings of the National Academy of Sciences of the United States of America·Karthikeyan KrishnamurthyGovindasamy Ilangovan
Apr 24, 2008·Molecular Medicine·James P Stice, Anne A Knowlton
Sep 10, 2014·Cell Stress & Chaperones·Kevin A MoranoValérie Mezger
May 18, 2016·Scientific Reports·Xiao-Yan PanShu-Wen Liu
Feb 7, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ziyan LuKhalilah L Gates
Aug 30, 2006·FEBS Letters·Pascal Hermann, Dirk A Dobbelaere
Dec 23, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Satoshi KubokiAlex B Lentsch
Sep 21, 2019·Physiological Reviews·Eoin P CumminsCormac T Taylor
Mar 24, 2009·Exercise and Sport Sciences Reviews·Michelle S Harkins

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