Evidence for a role of hexokinases as conserved glucose sensors in both monocot and dicot plant species.

Plant Signaling & Behavior
Jung-Il ChoJong-Seong Jeon

Abstract

The role of the hexokinases (HXKs) as glucose (Glc) sensors has been mainly demonstrated for Arabidopsis (Arabidopsis thaliana) HXK1 (AtHXK1) but has yet to be shown in other plant species. In our recent publication, we reported that two rice (Oryza sativa) HXKs, OsHXK5 and OsHXK6, also function as Glc sensors. These two enzymes harbor both mitochondrial targeting peptides (mTPs) and nuclear localization signals (NLSs), and we confirmed their dual-targeting ability to nuclei and mitochondria using GFP fusion experiments. Consistently, it has been previously known that AtHXK1 is predominantly associated with mitochondria but is also present in nuclei in vivo at appreciable levels. Notably, the expression of OsHXK5, OsHXK6, or their catalytically inactive mutant alleles complemented the Arabidopsis glucose insensitive2 (gin2) mutant. In addition, transgenic rice plants overexpressing OsHXK5 or OsHXK6 exhibited hypersensitive plant growth retardation and enhanced repression of the Rubisco small subunit (RbcS) gene in response to glucose treatment. Our results thus provided evidence that OsHXK5 and OsHXK6 can function as glucose sensors in rice. Hence, the available current data suggest that the role of the HXKs as Glc sensors may ...Continue Reading

References

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Mar 21, 2007·Plant Physiology·Rasika Lasanthi-KudahettigePierdomenico Perata
Oct 17, 2008·Phytochemistry·David Granot
Nov 18, 2008·Plant Physiology·Jung-Il ChoJong-Seong Jeon
Dec 26, 2008·Plant Physiology·Xiaodong DingWen-Yuan Song

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Citations

Mar 29, 2011·Journal of Experimental Botany·Li XiangWim Van den Ende
Nov 19, 2015·Proceedings of the National Academy of Sciences of the United States of America·Wenchao HuangYingguo Zhu
Oct 5, 2014·Journal of Experimental Botany·Elizabeth CordobaPatricia León
May 8, 2015·Journal of Integrative Plant Biology·Hyun-Bi KimJong-Seong Jeon
Aug 6, 2020·International Journal of Molecular Sciences·Dayong LiangShaoshan Li
Feb 11, 2015·Acta Crystallographica. Section D, Biological Crystallography·Juan FengTingyun Kuang
Aug 29, 2018·International Journal of Molecular Sciences·Soulaiman SakrRossitza Atanassova

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