PMID: 40031Jun 29, 1979

Evidence for a role of phosphatidyl ethanolamine as a modulator of membrane-membrane contact

The Journal of Membrane Biology
M A Kolber, D H Haynes


Phosphatidyl ethanolamine (PE) is shown to be effective in producing membrane aggregation. The aggregation of PE and PE/PC (phosphatidyl choline) mixed vesicles was studied as a function of pH and cation composition of the medium. The kinetics and equilibria were studied in stopped-flow rapid mixing experiments, in which PE vesicles prepared at pH 9.2 were "jumped" to pH 7. H+ ions protonate PE- and promote vesicle aggregation in a cooperative fashion. Vesicles containing PC have a decreased tendency to aggregate compared to pure PE vesicles. The apparent rate constant for aggregation was about two orders of magnitude below that for diffusion controlled aggregation and was virtually the same for PE and PE/PC mixed vesicles. A theoretical description of equilibrium for vesicle aggregation is developed in terms of three parameters: the equilibrium constant for the protonation of PE (KA), the equilibrium constant for aggregation (Keq) and the number of PE molecules in an effective area that the two vesicles must interact in order to aggregate (Neff). These parameters are compared with values and trends expected for electrostatic calculations based on dipolar repulsion and short-range binding, to which hydrogen bonding may contribu...Continue Reading


Jan 1, 1983·Journal of the Autonomic Nervous System·S J MorrisD H Haynes
Feb 1, 1982·Molecular and Biochemical Parasitology·S S McDiarmidS M Rahman
Aug 14, 1992·Biochimica Et Biophysica Acta·D C Litzinger, L Huang
Feb 15, 2001·Colloids and Surfaces. B, Biointerfaces·F NackaB Entressangles
Nov 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·E L Bearer, D S Friend
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J BentzF C Szoka
Apr 1, 1981·The Journal of General Physiology·S McLaughlinA McLaughlin
Oct 1, 1980·European Journal of Biochemistry·L KovácV Kovácová
Jun 11, 2011·Journal of Lipids·Sutapa Mondal Roy, Munna Sarkar
Jan 1, 1985·FEBS Letters·R M StraubingerD Papahadjopoulos
Aug 10, 1983·Biochimica Et Biophysica Acta·C G MorganB Hudson
Jun 18, 1985·Biochemistry·N DüzgüneşD Papahadjopoulos
Jun 18, 1985·Biochemistry·H EllensF C Szoka
Dec 21, 1979·Journal of Theoretical Biology·D H HaynesS J Morris


Jan 1, 1979·Membrane Biochemistry·S J MorrisD H Haynes
Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·V A ParsegianR P Rand
Dec 15, 1977·Biochimica Et Biophysica Acta·J G Stollery, W J Vail
Dec 21, 1979·Journal of Theoretical Biology·D H HaynesS J Morris
May 1, 1977·Biophysical Journal·D M LeNeveu, R P Rand
Jul 3, 1975·Biochimica Et Biophysica Acta·J Lansman, D H Haynes
Oct 1, 1975·Journal of Theoretical Biology·P M Dean, E K Matthews
Feb 19, 1976·Nature·D M LeNeveuV A Parsegian
Aug 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·P B HitchcockG G Shipley
Apr 12, 1974·Biochimica Et Biophysica Acta·K Colbow, B L Jones
May 30, 1974·Biochimica Et Biophysica Acta·D PapahadjopoulosW J Vail
May 1, 1965·Journal of Molecular Biology·J MONODJ P CHANGEUX

Related Concepts

Molar Tooth
Cell Adhesion
Hypotrichosis And Recurrent Skin Vesicles
Cell Aggregation

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.