PMID: 3215392Dec 1, 1988Paper

Evidence for a role of the Leydig cells in control of the intratesticular secretion of inhibin

Molecular and Cellular Endocrinology
R M SharpeS Maddocks

Abstract

Injection of adult male rats with human chorionic gonadotrophin (hCG) caused a dose- and time-dependent increase in the levels of immunoactive inhibin in testicular interstitial fluid (IF), which differed from the pattern of change in testosterone levels. Blockage of the hCG-induced increase in IF levels of testosterone, by administration of aminoglutethimide, only partially attenuated the increase in levels of inhibin. Inhibin levels in IF were only increased by doses of hCG which cause inflammatory changes and focal seminiferous tubule damage, but there was no association between the degree of tubule damage and inhibin levels. It is concluded that one or more luteinizing hormone (LH)-regulated, non-steroidogenic Leydig cell products may be involved in the paracrine control of inhibin secretion. These data are of clinical relevance and of potential physiological significance.

References

Feb 13, 1987·Biochemical and Biophysical Research Communications·Y EtoH Shibai
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A J HsuehW Vale
Sep 1, 1983·Journal of Reproduction and Fertility·R M Sharpe, I Cooper

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Citations

Aug 1, 1993·Cell and Tissue Research·M K VliegenE Nieschlag
Nov 1, 1989·Molecular and Cellular Endocrinology·S Maddocks, R M Sharpe
Oct 1, 1990·Molecular and Cellular Endocrinology·M Onoda, D Djakiew
Jan 1, 1990·Toxicology in Vitro : an International Journal Published in Association with BIBRA·R E Chapin, J Phelps
Apr 12, 2001·International Journal of Andrology·D Kinniburgh, R A Anderson
Apr 16, 1998·Equine Veterinary Journal·S NagataK Taya
Oct 13, 2006·Journal of Endocrinological Investigation·V A Giagulli, D Carbone
Apr 1, 1991·Toxicology and Applied Pharmacology·H P BrunA Cordier
Jan 1, 1989·Annals of the New York Academy of Sciences·C W BardinC L Chen
Mar 1, 1991·The Anatomical Record·S V GardeS A Kulkarni
Mar 4, 2015·Hernia : the Journal of Hernias and Abdominal Wall Surgery·E BlevrakisE Chrysos
Nov 7, 1998·Archives of Andrology·I SasagawaH Miura
May 1, 1992·Archives of Andrology·S B MoodbidriA R Sheth
Jul 1, 1990·Journal of Endocrinological Investigation·D M de KretserG P Risbridger

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