PMID: 9651491Jul 4, 1998Paper

Evidence for a role of the multidrug resistance protein (MRP) in the outward translocation of NBD-phospholipids in the erythrocyte membrane

Biochimica Et Biophysica Acta
D Kamp, C W Haest

Abstract

Phosphatidylserine (PS) containing a 7-nitrobenz-2-oxa-1, 3-diazol-4-yl- (NBD-) hexanoyl residue, like native PS, preferentially distributes into the inner membrane leaflet of human erythrocytes. In the case of NBD-PS, this preference results from two opposite active processes, an inward translocation mediated by the aminophospholipid flippase and an outward translocation mediated by an ill-defined floppase. Selective inhibition of this floppase by alkylating reagents or cationic and anionic drugs increases the extent of accumulation of NBD-PS in the inner membrane leaflet from about 70% in control cells to about 90%. Different inhibitor sensitivities of the flippase and the floppase strongly suggest that both represent different entities. The floppase was characterized in further detail by comparing inhibitory effects of various compounds on this translocase with their effects on known primary active transport systems for amphiphilic compounds. The inhibitory effects of various drugs, glutathione conjugates and GSSG on the floppase activity closely correlate with those reported for the active transport by the multidrug resistance protein (MRP) while only poorly going parallel with those for the active transport by the low affi...Continue Reading

References

Jan 1, 1992·Annual Review of Biophysics and Biomolecular Structure·P F Devaux
Jan 1, 1992·The American Journal of Physiology·M HeijnP L Jansen
Jan 1, 1991·Chemistry and Physics of Lipids·M ColleauP F Devaux
Jan 1, 1989·Canadian Journal of Physiology and Pharmacology·T R JonesP Masson
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M Bitbol, P F Devaux
Aug 1, 1971·The Journal of General Physiology·P A Knauf, A Rothstein
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·G J ZamanP Borst
Jan 1, 1995·The Journal of Membrane Biology·C R Leveille-Webster, I M Arias
Mar 8, 1995·Biochemical and Biophysical Research Communications·V GekelerJ Beck
Jul 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·B SarkadiR C Boucher
Apr 19, 1994·Biochemistry·A VondenhofC W Haest
May 11, 1994·Biochimica Et Biophysica Acta·R OrtweinB Deuticke
Jul 25, 1996·Biochimica Et Biophysica Acta·M V SerraC W Haest
Oct 11, 1996·Biochemical Pharmacology·D LautierS P Cole
Jan 1, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D Keppler, I M Arias
Jan 1, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R P ElferinkA K Groen
May 22, 1997·Biochimica Et Biophysica Acta·M HeijnJ Lankelma

❮ Previous
Next ❯

Citations

Apr 20, 2006·Pflügers Archiv : European journal of physiology·Ronald P J Oude Elferink, Coen C Paulusma
May 29, 2004·Biochimica Et Biophysica Acta·Robert F A ZwaalEdouard M Bevers
May 27, 2005·Life Sciences·Barbara Łania-PietrzakYoshiaki Shirataki
Jan 19, 2000·Trends in Biochemical Sciences·R W JohnstoneM J Smyth
Jun 17, 2000·Biochimica Et Biophysica Acta·P BorstA van Helvoort
Aug 14, 1999·Biochimica Et Biophysica Acta·E M BeversR F Zwaal
Aug 19, 2000·The Biochemical Journal·D W DekkersR F Zwaal
Dec 10, 2002·Annual Review of Physiology·Krishnakumar Balasubramanian, Alan J Schroit
Oct 4, 2011·Journal of Ethnopharmacology·Tolga Eichhorn, Thomas Efferth
Dec 27, 2005·FEBS Letters·Gerrit van MeerMaarten R Egmond
May 8, 2007·Archives of Biochemistry and Biophysics·Santosh Kumar SahuGopala Krishna Aradhyam
Apr 17, 2007·Blood Cells, Molecules & Diseases·Gaëtan DecherfSerge L Y Thomas
Oct 28, 2003·Hematological Oncology·Brian L Abbott
Nov 21, 2008·Cellular & Molecular Biology Letters·Olga WesołowskaKrystyna Michalak
Apr 22, 2014·Biochimica Et Biophysica Acta·Rosa L López-MarquésMichael G Palmgren
Oct 30, 2012·Biochimica Et Biophysica Acta·Jonathan A ColemanRobert S Molday
Mar 24, 1999·Molecular Membrane Biology·S FrickenhausR Heinrich
Mar 13, 2008·Biochimica Et Biophysica Acta·Hugo O van GenderenChris P M Reutelingsperger
Aug 3, 2011·Biochimica Et Biophysica Acta·Michal CiolkowskiMaria Bryszewska
Dec 3, 1999·Biochimica Et Biophysica Acta·D R HipfnerS P Cole
Jan 11, 2002·Blood Cells, Molecules & Diseases·M Bobrowska-HägerstrandH Hägerstrand
Apr 9, 2001·Seminars in Cell & Developmental Biology·T PomorskiG van Meer
May 12, 2009·Chemico-biological Interactions·Irving L M H AyeJeffrey A Keelan
Nov 5, 2016·Progress in Lipid Research·Thomas Günther Pomorski, Anant K Menon
Apr 5, 2002·Medicinal Research Reviews·J Middleton Boon, Bradley D Smith
Aug 2, 2003·Molecular Membrane Biology·Malgorzata Bobrowska-HägerstrandHenry Hägerstrand
Feb 11, 2003·Journal of Lipid Research·David L Daleke
Jun 4, 2004·The Journal of Biological Chemistry·Nanette KälinGerrit van Meer
Oct 30, 2004·Molecular Membrane Biology·Andreas BootsveldCees W M Haest
Mar 29, 2014·Circulation Research·Valerie B O'DonnellSteve P Watson
Apr 9, 2008·Current Opinion in Hematology·David L Daleke
Nov 30, 2006·The Journal of Biological Chemistry·David L Daleke
Mar 22, 2007·The Journal of Biological Chemistry·Christine L HammondNazzareno Ballatori
Jan 10, 2009·The Biochemical Journal·Alena Siarheyeva, Frances J Sharom
May 21, 2005·The Journal of Biological Chemistry·Nele Alder-BaerensAndreas Herrmann
May 9, 2003·Biological & Pharmaceutical Bulletin·Makiko ShimizuMasamichi Fukuoka

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