Evidence for a role of tumor necrosis factor alpha in disturbances of triglyceride and glucose metabolism predisposing to coronary heart disease

Metabolism: Clinical and Experimental
S JovingeJ Nilsson

Abstract

Elevated plasma levels of triglyceride-rich lipoproteins, a decreased high-density lipoprotein (HDL) cholesterol concentration, hyperinsulinemia, and impaired fibrinolytic function frequently aggregate in patients with premature coronary heart disease (CHD). Experimental studies suggest that the cytokine tumor necrosis factor alpha (TNFalpha) produced by adipocytes plays a part in the regulation of triglyceride and glucose metabolism. The present study examined whether TNFalpha is implicated in these metabolic and fibrinolytic disturbances in young postinfarction patients. TNFalpha levels were determined in two groups of young (age <45 years) male postinfarction patients (n = 92 and 60) and in matched, population-based control subjects (n = 63). Plasma TNFalpha was higher in patients than in controls (4.1 +/- 1.6 v2.5 +/- 0.4 pg/mL, P < .0001). In hyperlipidemic patients, TNFalpha levels correlated significantly with the concentrations of very-low-density lipoprotein (VLDL) triglyceride and cholesterol and negatively with HDL cholesterol. Treatment with bezafibrate decreased VLDL triglycerides and increased HDL cholesterol, but did not affect TNFalpha levels. The TNFalpha concentration also correlated significantly with fasting...Continue Reading

References

Jan 1, 1989·Annual Review of Immunology·B Beutler, A Cerami
May 1, 1989·Endocrinology·K R FeingoldC Grunfeld
Jan 1, 1986·British Heart Journal·A HamstenL Mettinger
Jan 1, 1973·Journal of Clinical Pathology. Supplement (Association of Clinical Pathologists)·K Carlson
May 1, 1984·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·G M Reaven, C E Mondon
Sep 1, 1981·The Journal of Experimental Medicine·M Kawakami, A Cerami

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Citations

Jul 18, 2003·Current Diabetes Reports·Waleed Aldhahi, Osama Hamdy
Feb 5, 2009·Current Diabetes Reports·Dario A GutierrezAlyssa H Hasty
Feb 20, 2004·Current Hypertension Reports·Undurti N Das
Aug 2, 2005·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·M G CavalloM Arca
Nov 20, 2003·Nutrition·Undurti N Das
Jul 10, 2003·The Journal of Surgical Research·Ralph G DePalmaMark R Hall
Apr 20, 2001·Nutrition·U N Das
Jul 3, 2002·Nutrition·Undurti N Das
Jun 17, 2006·Nature Reviews. Immunology·Göran K Hansson, Peter Libby
Mar 23, 2002·The Pharmacogenomics Journal·M Pirmohamed, D J Back
Apr 12, 2001·Clinical and Experimental Dermatology·K J Smith, H G Skelton
Dec 16, 2011·The Journal of Biological Chemistry·Da LinChristopher A O'Callaghan
Jun 8, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C H BoltonJ H Pinkney
Sep 5, 2008·Current Opinion in Lipidology·Jan NilssonHarry Björkbacka
Feb 5, 2005·Pathophysiology of Haemostasis and Thrombosis·Marie-Christine AlessiIrene Juhan-Vague
Aug 6, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Ann B NguyenJames A de Lemos
Sep 20, 2005·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Simona GwozdziewiczováJirí Hrebícek
Jan 21, 2014·Cardiology in Review·Georgios ChristodoulidisConstantine E Kosmas
Aug 24, 2012·Canadian Journal of Physiology and Pharmacology·Ram B SinghDouglas W Wilson
Jan 19, 2012·Diabetes & Metabolism·M C Calle, M L Fernandez
Jul 22, 2009·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Zhen LiQi Cui
Jan 17, 2007·Metabolism: Clinical and Experimental·Serena TonstadIngebjørg Seljeflot
Jan 14, 2009·Journal of Clinical Laboratory Analysis·Carmen M Gurrola-DíazJosé F Muñoz-Valle

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