PMID: 8584446Jan 1, 1996Paper

Evidence for a specific site for modulation of calcium channel activation by external calcium ions

Pflügers Archiv : European journal of physiology
G W Zamponi, T P Snutch

Abstract

We have investigated the effect of permeant ion species on activation of transiently expressed neuronal alpha1A Ca channels. Equimolar replacement of Ba with Ca resulted in a consistent depolarizing shift of the half-activation potential whose magnitude (∼10 mV) was constant over a range of 2 to 100 mM permeant ion, suggesting that the effects of Ca ions were fully developed at concentrations below 2 mM and indicating that Ba and Ca screened surface charges equally. In mixtures of Ba and Ca at constant divalent cation concentration the voltage-shift, as a function of Ca mole fraction, was well described by a model in which Ba and Ca compete for a single site but only Ca ions produce a gating effect. Overall, our data are consistent with Ca ions exerting their effects on activation via a specific regulatory site.

Citations

May 26, 2011·Pflügers Archiv : European journal of physiology·Thierry CensPierre Charnet
Jul 30, 2008·The Journal of General Physiology·Nilofar KhanStephen W Jones
Mar 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ofer WiserDaphne Atlas
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·D W HamiltonM R Blatt
Apr 30, 2003·Biophysical Journal·Adrián Rodríguez-Contreras, Ebenezer N Yamoah
Nov 19, 2011·British Journal of Pharmacology·David J AdamsGéza Berecki
Mar 31, 2015·Progress in Neurobiology·Felix NeumaierToni Schneider
Jun 22, 2018·Pflügers Archiv : European journal of physiology·Andrés M BaraibarRicardo Borges
Aug 15, 2008·Journal of Neurophysiology·Adrian Rodriguez-ContrerasEbenezer N Yamoah
Dec 20, 2000·The Journal of Biological Chemistry·Z P FengG W Zamponi
Aug 26, 1998·The Journal of Biological Chemistry·M C JeziorskiP A Anderson
Apr 4, 2003·The Journal of Biological Chemistry·J David SpaffordGerald W Zamponi
Oct 17, 1998·Journal of Neurophysiology·M B McFarlane, W F Gilly

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