Evidence for a stimulatory role of follicle-stimulating hormone on the spermatogonial population in adult males

Fertility and Sterility
Carlo ForestaMarco Rossato

Abstract

To evaluate the effects of treatment with FSH on seminal indices and on the seminiferous epithelium of oligozoospermic subjects with normal FSH plasma levels. Placebo-controlled, double-blind randomized study. Academic setting. Ninety subjects with idiopathic oligozoospermia (sperm count of < 10 x 10(6)/mL) and normal plasma levels of FSH. Three months of treatment with FSH (60 patients) or placebo (30 patients); bilateral testicular fine-needle aspiration. Seminal indices; testicular cytologic features; plasma levels of FSH, LH, and testosterone; and ultrasonographic testicular examination. According to seminal indices, patients treated with FSH and placebo were classified as nonresponders or as responders (as determined by at least a doubling of sperm count). No placebo-treated patients responded to treatment. Among FSH-treated patients, 20 responded to hormonal treatment and 40 did not. The results of pretreatment cytologic examination of testicular specimens from patients who did not respond to FSH treatment were consistent with hypospermatogenesis associated with maturational disturbances at the spermatid level. In contrast, patients who responded to treatment with FSH had isolated hypospermatogenesis without maturational ...Continue Reading

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Citations

Apr 25, 2012·Current Treatment Options in Oncology·Landon W Trost, Robert E Brannigan
Apr 16, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Kaan AydosOzden Tolunay
Apr 25, 2000·Molecular and Cellular Endocrinology·C ForestaM Rossato
Dec 12, 2012·Nature Reviews. Urology·Daniela ValentiAldo E Calogero
Dec 15, 2000·International Journal of Andrology·D A Adamopoulos
Jun 24, 2006·Reproductive Biomedicine Online·Andrea M IsidoriAldo Isidori
Dec 8, 2007·Reproductive Biomedicine Online·C ForestaA Garolla
Jul 28, 2011·International Journal of Andrology·R SeliceC Foresta
Jun 24, 2010·International Journal of Andrology·R SeliceC Foresta
Jul 9, 2003·International Journal of Andrology·Dimitrios AdamopoulosAchilleas Gregoriou
Apr 20, 2016·Nature Reviews. Urology·Martin Kathrins, Craig Niederberger
Apr 22, 2009·Expert Opinion on Biological Therapy·Carlo ForestaAndrea Garolla
Dec 20, 2007·Growth Factors·Mahmoud HuleihelEitan Lunenfeld
Jul 9, 2004·Fertility and Sterility·Helmy A SelmanImam El-Danasouri
Aug 24, 2013·The Cochrane Database of Systematic Reviews·Abdelhamid M AttiaHesham G Al-Inany
Oct 14, 2014·Clinical and Experimental Reproductive Medicine·Jae Hung Jung, Ju Tae Seo
Oct 4, 2008·Current Opinion in Urology·Carlo ForestaAlberto Ferlin
Jul 6, 2019·Asian Journal of Andrology·Rossella CannarellaAldo E Calogero
Dec 25, 2019·Andrology·Manuela Simoni, Daniele Santi
May 9, 2000·Journal of Endocrinological Investigation·S ZarrilliM De Rosa
Nov 1, 2008·Expert Review of Endocrinology & Metabolism·Carlo ForestaAlberto Ferlin
May 20, 2020·Journal of Clinical Medicine·Maurizio De Rocco PonceAndrea Garolla

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