PMID: 45326Jan 1, 1979

Evidence for a strong non-adrenergic component in the motor transmission to the rabbit vas deferens

West African Journal of Pharmacology and Drug Research
A O Adebanjo, N Ambache


Isolated vas deferens preparations from 16 rabbits of the New Zealand white strain were subjected to electrical and chemical excitability under physiological conditions and under the influence of drugs. Such smooth muscle fibres were strictly confined to the terminal 3 cm. segments of the distal 'urethral' portions of the vasa deferentia. Intermittent field stimulation, at 60 second intervals, was provided by a stimulator of low output impedance under constant parameters of voltage, pulse width and frequency. Results from this investigation revealed the undermentioned anomalous but distinct findings viz: (a) the presence of a minor adrenergic component which disappeared in phentolamine but remained unaffected by prolonged exposures to phenoxybenzamine; (b) the presence of a predominantly non-adrenergic component which was totally refractory to phenoxybenzamine but suffered a weak diminution in phentolamine; and (c) the picture of a phentolamine-insensitive but twitch-inhibiting effect shared by both tyramine and noradrenaline. Rabbit vasa consistently displayed a remarkable insensitivity to the motor effects of submicromolar concentrations of the putative neurotransmitter substance i.e. noradrenaline. The indirect sympathomimet...Continue Reading

Related Concepts

Electric Impedance
Synaptic Transmission
Contraction (Finding)
Smooth Muscle
Plant fiber
Norepinephrine, (+, -)-Isomer
Adrenergic alpha-Antagonists

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