Evidence for a strychnine-sensitive mechanism and glycine receptors involved in the control of urethral sphincter activity during micturition in the cat

Experimental Brain Research
S J ShefchykR R Buss

Abstract

Micturition in the decerebrate cat is characterized by a coordinated bladder contraction and a simultaneous decrease in external urethral sphincter (EUS) efferent activity. Without the suppression of EUS activity, voiding is significantly impaired, resulting in a state sometimes referred to as bladder-sphincter dyssynergia. The aim of the present study was to determine whether glycinergic inhibition contributes to the suppression of EUS activity during micturition evoked by bladder distension or electrical stimulation of the pontine micturition center (PMC) in decerebrate cats. Using subconvulsive intravenous doses of strychnine (0.1-0.24 mg/kg), we examined changes in bladder and EUS electroneurographic (ENG) activity during micturition. Following subconvulsive doses of strychnine, tonic EUS ENG activity increased during bladder filling in five of six animals. In the presence of strychnine, it was possible to evoke reflex bladder contractions of similar duration and peak pressure to those observed before strychnine administration. However, there was an absence of suppression of EUS ENG activity during the bladder contractions in all the animals. To determine whether the changes in sphincter activity could be due to strychnine ...Continue Reading

Citations

Jun 20, 2003·The Journal of Physiology·Robert R Buss, Susan J Shefchyk
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·W C de Groat, N Yoshimura
May 21, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Karl B Thor, William C de Groat
Feb 20, 2004·Archives of Physiology and Biochemistry·M HeldoornJ Vanderschoot
Mar 16, 2000·The Journal of Physiology·K L Paroschy, S J Shefchyk
Sep 8, 2009·Life Sciences·Katsumi KadekawaSeiichi Saito
Aug 29, 2007·Neurourology and Urodynamics·Samih Al-HayekPaul Abrams
Feb 10, 2004·The Journal of Urology·Minoru MiyazatoYoshihide Ogawa
Nov 11, 2005·The Journal of Urology·Minoru MiyazatoYoshihide Ogawa
Jul 18, 2008·American Journal of Physiology. Renal Physiology·Sung-Lang ChenTzer-Bin Lin
Oct 19, 2012·Journal of Neurophysiology·Tyler K BestEdward C Burgard
Dec 17, 2004·Pharmacological Reviews·Karl-Erik Andersson, Alan J Wein
Aug 22, 2014·American Journal of Physiology. Renal Physiology·Meredith J McGeeWarren M Grill
Apr 4, 2000·Physiological Reviews·J C ReklingJ L Feldman

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