PMID: 1195141Oct 1, 1975Paper

Evidence for a transient potassium membrane current dependent on calcium influx in crab muscle fibre

The Journal of Physiology
Y Mounier, G Vassort

Abstract

1. Voltage-clamp experiments were achieved on crab muscle fibre with the double sucrose-gap technique. 2. The accuracy of the imposed voltage has been controlled with an impaled micro-electrode connected to an external circuit. 3. Step depolarizations elicit two kinds of records. In type I fibres, the initial current exhibits only an inward calcium component. In type II fibres, the initial current exhibits a hump, transient outward current, mixed with the calcium current; these fibres exhibit always action potentials with fast repolarization. 4. A potassium origin is suggested for this outward current, due to its dependence on [K]o and its inhibition by TEA. 5. In fibres with a composite initial current, the voltage dependence of the availability of the measured inward current appears complex. It can be shown to be the sum of a simple calcium inactivation (which is observed alone in TEA solution) and a fast potassium inactivation. This potassium conductance is nearly half-available at the resting membrane potential. 6. The origin of the transient outward current is tentatively described. Consecutive to a transient internal increase of calcium ions (due to the calcium current) its activation curve is shifted in an hyperpolarizin...Continue Reading

Citations

Aug 1, 1995·Pflügers Archiv : European journal of physiology·A Araque, W Buño
Jan 1, 1985·Progress in Biophysics and Molecular Biology·J CailléO Rougier
Jul 8, 1988·Neuroscience Letters·J LehouelleurJ Bruner
Aug 1, 1979·Archives internationales de physiologie et de biochimie·Y Mounier
Nov 1, 1986·Pflügers Archiv : European journal of physiology·M Gho, A Mallart
Feb 1, 1982·Pflügers Archiv : European journal of physiology·E Coraboeuf, E Carmeliet
Apr 25, 1977·Pflügers Archiv : European journal of physiology·G Suarez-Kurtz, A L Sorenson
Nov 1, 1979·The American Journal of Physiology·R J WeigelC L Prosser
Jun 1, 1988·Neuroscience·B Rudy
Feb 25, 1991·Biochimica Et Biophysica Acta·T KrüppelW Lueken

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