PMID: 6164047Feb 11, 1981Paper

Evidence for a unique human fibroblast interferon (IFN-beta 1) chromosomal gene, devoid of intervening sequences

Nucleic Acids Research
J TavernierW Fiers

Abstract

Direct restriction analysis of the human genome, using the Southern transfer technique and hybridization with a human fibroblast interferon (IFN-beta) complementary DNA insert probe, revealed the presence of a single gene; no additional closely related IFN-beta genes could be detected. A lambda-linked human gene library (Lawn et al., Cell, 15, 1157-1174 (1978)) was screened using the cDNA probe. Out of 600,000 recombinant phage examined, one single clone bearing interferon sequences was obtained. Restriction analysis of the relevant region revealed an identical restriction map as obtained for the IFN-beta 1 cDNA clones. No intervening sequences could be detected, either in the coding or the non-coding regions of the gene.

References

Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G M WahlG R Stark
Nov 24, 1979·Nucleic Acids Research·H C Birnboim, J Doly
Nov 24, 1979·Nucleic Acids Research·B VennströmL Philipson
Oct 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M Grunstein, D S Hogness
Apr 1, 1973·The Journal of General Virology·A BilliauP De Somer
Jan 1, 1980·Scandinavian Journal of Immunology·K Berg, I Heron
Jun 1, 1980·Gene·T TaniguchiM Muramatsu
Sep 25, 1980·Nucleic Acids Research·D V GoeddelS Pestka
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·W P LevyS Pestka
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·S SteinS Pestka
Jun 1, 1980·Gene·D Hanahan, M Meselson

❮ Previous
Next ❯

Citations

Jan 1, 1986·Molecular Biology Reports·W DegraveW Fiers
Dec 1, 1987·Experientia·M C Horzinek
Jan 1, 1985·Pharmacology & Therapeutics·J A Langer, S Pestka
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·N B Raj, P M Pitha
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·K ZinnT Maniatis
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D Canaani, P Berg
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·P B SehgalM Inouye
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·N B Raj, P M Pitha
Feb 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·J IrschA H Radbruch
Sep 1, 1982·The Journal of Experimental Medicine·A D SagarF H Ruddle
Jan 1, 1982·Journal of Interferon Research·E Dworkin-RastlP Swetly
May 25, 1982·Nucleic Acids Research·D SkupE De Maeyer
Jul 11, 1983·Nucleic Acids Research·R DevosW Fiers
Feb 11, 1983·Nucleic Acids Research·G D ShawC Weissmann
May 11, 1984·Nucleic Acids Research·J HiscottC Weissmann
Feb 11, 1985·Nucleic Acids Research·E C ZwarthoffJ Trapman
Jun 15, 1983·European Journal of Biochemistry·J ShuttleworthD C Burke
Mar 1, 2003·Journal of Virology·Vivian RuvoloSankar Swaminathan
Aug 1, 1985·Journal of Medical Genetics·C DeromP Pearson
Apr 15, 1985·International Journal of Cancer. Journal International Du Cancer·R A Hekman, J Trapman
Aug 20, 1981·Nature·M D EdgeA F Markham
Dec 4, 1984·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J HiscottC Weissmann
Sep 24, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·W FiersJ Content
Sep 24, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C WeissmannU Weidle
Sep 30, 1982·Biochimica Et Biophysica Acta·P B Sehgal
May 1, 1982·Molecular and Cellular Biology·P M PithaF H Ruddle
Feb 1, 1983·Molecular and Cellular Biology·S Mayrand, T Pederson
Mar 23, 1984·Science·A D SagarF H Ruddle

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.