PMID: 3755295Jul 1, 1986Paper

Evidence for a vasodilatory effect of vasopressin in the conscious rat

The American Journal of Physiology
B R Walker

Abstract

Experiments were performed on conscious, chronically instrumented rats to determine the cardiovascular effects of intravenous arginine vasopressin (AVP) with and without V1-vasopressinergic antagonist administration. This design allowed the assessment of the cardiovascular effects of high circulating levels of AVP in the absence of the direct vasoconstrictor properties of the hormone. One group of rats (n = 10) were administered a constant infusion of AVP (2.5 mU/min iv) for 40 min and demonstrated increased mean arterial blood pressure (MABP) and total peripheral resistance (TPR), while heart rate (HR) and cardiac output (CO) fell. Another group of animals (n = 7) also received AVP for 40 min; however, at 25 min of the infusion, 10 micrograms/kg of d(CH2)5Tyr(Me)AVP was given intravenously. Administration of this V1-vasopressinergic antagonist caused MABP and TPR to fall below pre-infusion levels, although AVP infusion continued. HR and CO returned to control. Additional experiments showed no effect of the antagonist (n = 8) or AVP vehicle (n = 7) alone on the measured hemodynamic variables. In addition, pretreatment with the cyclooxygenase inhibitor meclofenamate did not affect the observed vasodilation in AVP-treated animals...Continue Reading

Citations

Aug 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C R CookeT Mangold
Sep 10, 2010·American Journal of Physiology. Renal Physiology·Lise BankirNadine Bouby
Dec 17, 2016·Internal Medicine·Yusuke AdachiHideo Fujita
Oct 18, 2012·Physiological Reviews·Taka-aki KoshimizuAkito Tanoue

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