Evidence for a vasomotor cyclo-oxygenase dependent mechanism of sensitization at the cutaneous level

British Journal of Clinical Pharmacology
G MahéS Durand

Abstract

Current-induced vasodilation (CIV) is an axon-reflex response observed during monopolar current application such as iontophoresis. Cyclo-oxygenase derivates (COD) participate in CIV and act as sensitizing agents at the anodal level. Mechanisms involved during cathodal current application (CCA) are partially unknown. In a randomized double-blind crossover trial, we tested in 16 healthy subjects (i) the influence of the inter-stimulation interval (I-I) by comparing CIV following all-at-once 10 s CCA against 2 × 5 s CCA with intervals ranging from15 s-16 min and (ii) the participation of COD in CIV using 1 g aspirin or placebo intake. Measurements were repeated 2 h and 14 days after treatment. Laser Doppler flowmetry assessed cutaneous blood flow, reported in multiples of baseline. Before treatment, peak vasodilation 10 min after the last current application (CVCstim2 ) increased compared with baseline whatever the I-I. Increase in CVCstim2 from baseline was greater for the 4 min (9.4 (5.3, 10.9) times; median (1(st) percentile, 3(rd) percentile)) and higher I-Is compared with all-at-once delivery (3.0 (2.1, 4.3) times, P < 0.05). The response was similar after placebo but aspirin abolished this vasodilation (increase by 1.2 (1.1,...Continue Reading

Associated Clinical Trials

References

Sep 29, 2007·The Journal of Physiology·Santiago Lorenzo, Christopher T Minson
Sep 10, 2010·The Journal of Investigative Dermatology·Stéphanie GohinBérengère Fromy
Jan 19, 2012·Circulation. Cardiovascular Imaging·Guillaume MahéPierre Abraham
Nov 23, 2012·Journal of Applied Physiology·Jean-Luc CracowskiClaire Millet
May 1, 2013·Microvascular Research·Pierre AbrahamGuillaume Mahe
Dec 21, 2013·Journal des maladies vasculaires·C PuissantG Mahé

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