Evidence for a vesicular transport mechanism in hepatocytes for biliary secretion of immunoglobulin A

Science
R H RenstonB J Underdown

Abstract

Quantitative electron microscopic autoradiography and diaminobenzidine cytochemistry provide evidence for an uptake and vesicular transport mechanism for iodine-125-labeled immunoglobulin A from plasma to bile by hepatocytes in vivo. The data confirm the existence of a hepatobiliary pathway for secretion of immunoglobulin A into the intestine and are consistent with a vesicular transport mechanism for biliary proteins within liver parenchymal cells.

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Proceedings of the National Academy of Sciences of the United States of America
M M FisherB J Underdown
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