PMID: 7537517May 1, 1995Paper

Evidence for a weak angiogenic response to human colorectal cancers

British Journal of Cancer
A J PritchardR E Hewitt

Abstract

Many previous qualitative studies have shown that tumours are less vascular in the centre, and that host tissues become more vascular in close proximity to tumours. However, quantitative findings presented here for human colorectal cancer reveal some significant differences. Sections from 20 colorectal carcinomas (ten moderately and ten poorly differentiated) were immunostained with the QB/end/10 monoclonal to demonstrate blood vessels. These were measured by interactive morphometry and vascular volume density, surface density (Sv) and length density were recorded. In poorly differentiated carcinomas, the tumour centre was significantly less vascular than the periphery for all three parameters (P = 0.008 for Sv). However, no significant difference was seen for moderately differentiated tumours, which constitute the majority of colorectal cancers. Surrounding host tissues did not show a general increase in vascular density close to tumours. Furthermore, when total viable tissue was considered, the vascular density of carcinomas was not markedly different from normal mucosa. In the centre of moderately differentiated carcinomas for example, the mean value for Sv was only 1.4 times higher than the mean value for normal mucosa. The...Continue Reading

Citations

Dec 13, 2000·The Journal of Pathology·R E HewittM Tsoskas
Mar 14, 2002·Head & Neck·Ronald Schimming, Dieter Marmé
Apr 10, 2003·Virchows Archiv : an International Journal of Pathology·Gian KayserKlaus Kayser
Feb 21, 2008·American Journal of Rhinology·Shahzada K AhmedStuart Egginton
Oct 26, 2001·Scandinavian Journal of Urology and Nephrology·J H MydloW Thelmo
Mar 1, 1999·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland· Ogawa Tokunaga

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