Evidence for acute renal cortical vasoconstriction after uninephrectomy

Renal Failure
D W MoskowitzE E Simon

Abstract

The rate of progression of chronic renal failure (CRF) is similar for many diseases, suggesting a common, perhaps intrinsic, renal signal for its progression. The remnant nephron hypothesis of Bricker suggests that CRF may be the result of persistent compensatory renal growth (CRG). Normally, CRG after unilateral nephrectomy (uniNx) ceases within 1 week. Knowledge of the signals that initiate CRG may therefore shed light on the signals responsible for ongoing CRF. The signals responsible for the initiation of compensatory renal growth after uniNx are unknown. Hemodynamic changes in the remaining renal artery have been observed, but there are as yet no data for the main renal compartment which undergoes hypertrophy, the superficial renal cortex. The noninvasive technique of laser-Doppler flowmetry allows the continuous and independent monitoring of blood velocity and blood volume. The product of the two signals is proportional to tissue blood flow per unit volume of the tissue observed. Under controlled conditions in adult male Sprague-Dawley rats, renal cortical blood velocity increased by 22% within 5 min after uniNx and remained elevated at this level for 60 min. Renal cortical blood volume decreased throughout the experiment...Continue Reading

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Citations

Jan 5, 2000·Kidney International·V GrossF C Luft
Apr 11, 2003·Diabetes Technology & Therapeutics·David W Moskowitz
Oct 25, 2002·Diabetes Technology & Therapeutics·David W Moskowitz
Jul 23, 2003·Diabetes Technology & Therapeutics·D W Moskowitz

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