Evidence for ADAR-induced hypermutation of the Drosophila sigma virus (Rhabdoviridae).

BMC Genetics
Jennifer A CarpenterFrancis M Jiggins

Abstract

ADARs are RNA editing enzymes that target double stranded RNA and convert adenosine to inosine, which is read by translation machinery as if it were guanosine. Aside from their role in generating protein diversity in the central nervous system, ADARs have been implicated in the hypermutation of some RNA viruses, although why this hypermutation occurs is not well understood. Here we describe the hypermutation of adenosines to guanosines in the genome of the sigma virus--a negative sense RNA virus that infects Drosophila melanogaster. The clustering of these mutations and the context in which they occur indicates that they have been caused by ADARs. However, ADAR-editing of viral RNA is either rare or edited viral RNA are rapidly degraded, as we only detected evidence for editing in two of the 104 viral isolates we studied. This is the first evidence for ADARs targeting viruses outside of mammals, and it raises the possibility that ADARs could play a role in the antiviral defences of insects.

References

Sep 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·L SharmeenM Groudine
Sep 1, 1995·Journal of Virology·A M Hajjar, M L Linial
Jan 1, 1996·Journal of Neurochemistry·P H Seeburg
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·M Kumar, G G Carmichael
Feb 3, 2000·Journal of Neurogenetics·L A SmithJ C Hall
Aug 3, 2001·The EMBO Journal·A D Scadden, C W Smith
Nov 21, 2001·Nature Reviews. Genetics·L P KeeganM A O'Connell
Oct 26, 2002·Proceedings of the National Academy of Sciences of the United States of America·Swee Kee Wong, David W Lazinski
Aug 9, 2003·Science·Barry HoopengardnerRobert Reenan
May 17, 2005·Nature Structural & Molecular Biology·A D J Scadden
May 20, 2005·Current Opinion in Cell Biology·Joshua DeCerbo, Gordon G Carmichael
Mar 27, 2007·Cold Spring Harbor Symposia on Quantitative Biology·R GuG G Carmichael
Aug 30, 2007·Molecular Ecology·Jennifer A CarpenterFrancis M Jiggins
May 9, 2008·Nature·Yoshinori KawamuraHaruhiko Siomi

❮ Previous
Next ❯

Citations

May 18, 2013·Developmental and Comparative Immunology·Jie Xu, Sara Cherry
Mar 10, 2015·Trends in Cell Biology·Melody M H LiCharles M Rice
Nov 17, 2011·Seminars in Cell & Developmental Biology·Alekos Athanasiadis
Mar 10, 2018·Viruses·William H PalmerRonald P van Rij
Jul 27, 2018·Annual Review of Virology·Patrick T DolanRaul Andino
Jul 1, 2020·Science Advances·Salvatore Di GiorgioSilvestro G Conticello
Jun 1, 2017·RNA·Liam KeeganMary O'Connell
Jun 27, 2017·Ecology and Evolution·Helen PiontkivskaMarta L Wayne
Jul 25, 2019·BMC Evolutionary Biology·Umberto RosaniPaola Venier
Sep 30, 2020·Archives of Microbiology·T G VillaA Sánchez-Pérez
Sep 6, 2020·Molecular Genetics and Genomics : MGG·Yue LiWenqing Jiang
Jan 29, 2020·Developmental and Comparative Immunology·Mengyu ShiChan Ding
Sep 17, 2020·Science Advances·Salvatore Di GiorgioSilvestro G Conticello
Aug 18, 2021·Emerging Microbes & Infections·Josep GregoriJosep Quer
Oct 26, 2021·Genome Biology and Evolution·Helen PiontkivskaMarta L Wayne

❮ Previous
Next ❯

Datasets Mentioned

BETA
AM689308
AM691026
DM113
GQ451695
GQ451693

Methods Mentioned

BETA
PCR

Software Mentioned

ADAR

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

BK Virus Infection

BK virus infection is a significant complication of modern immunosuppression used in kidney transplantation. Discover the latest research on BK virus infection here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.