Evidence for alcohol anti-craving properties of memantine

European Journal of Pharmacology
S M HölterR Spanagel

Abstract

Rats consuming alcohol voluntarily for a long time show increased alcohol consumption after a phase of alcohol deprivation and this might reflect increased craving for alcohol. Administration of memantine (1-amino-3,5-dimethyl-adamantane), a clinically used uncompetitive NDMA receptor antagonist, resulted in a significant reduction of the alcohol deprivation effect without any sedative, dysphoric or stimulant side-effects. The dose of memantine used (4.8 mg/day) resulted in serum levels close to the therapeutic range in humans. These results indicate that memantine may have therapeutical potential as an anti-craving drug for alcohol.

References

Jun 3, 1996·European Journal of Pharmacology·R SpanagelW Zieglgänsberger

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Citations

May 21, 2005·Alcohol·Thomas HillemacherStefan Bleich
Oct 1, 1998·European Journal of Pharmacology·J PiaseckiP Bienkowski
Jun 14, 2003·Pharmacology & Therapeutics·John H KrystalD Cyril D'Souza
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May 23, 2019·Neuropsychobiology·Lars Hendrik MüschenMarc André Nicolas Muschler

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