Evidence for altered proliferative ability of progenitors of urothelial cells in interstitial cystitis

The Journal of Urology
A ElgavishR Reed

Abstract

Secondary cultures of basal urothelial cells isolated from patients with stress incontinence (7 patients), neurogenic bladder (2 patients), interstitial cystitis (IC) (27 patients), bladder rupture (1 patient) and bacterial cystitis (3 patients) grew under growth restricting conditions. All groups displayed reproducible colony size distribution, reflecting the proliferative potential distribution in the population of progenitor cells seeded. The percentage of large colonies (> 6 cells/colony), progeny of basal cells with high proliferative potential, was low in cultures from control patients with stress incontinence, neurogenic bladder or bladder rupture. Exposure of cultures from control patients with stress incontinence to lipoteichoic acid from Streptococcus faecalis, in vitro, increased the percentage of large colonies to levels statistically indistinguishable from those in untreated IC cultures. This supported the possibility that exposure of progenitors of urothelial cells to infection in vivo may cause the persistent increase in the percentage of large colonies in 80% of the IC patients tested. Given these findings, it was not surprising that the percentage of large colonies was also high in cultures from patients with a...Continue Reading

References

Aug 1, 1992·Microbial Pathogenesis·J HyzyM Stinson
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Citations

Jun 15, 1999·Urology·P C SteinC L Parsons
Sep 24, 1999·Journal of Women's Health & Gender-based Medicine·D R Erickson
Jun 6, 2014·BioMed Research International·Susan K KeayToby C Chai
Jun 1, 2007·BJU International·Jennifer SouthgateIan Eardley
Jan 15, 2004·Anesthesiology Clinics of North America·Claudio A FelerJulius Fernandez

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