Evidence for an A2 adenosine receptor in human coronary arteries

European Journal of Pharmacology
M V RamagopalS J Mustafa

Abstract

The present study was an attempt to characterize the type of adenosine receptor in human coronary arteries obtained from organ donors with the use of adenosine analogs. Prostaglandin F2 alpha (10(-6) M) produced tonic contractions followed by phasic contractions and diltiazem (10(-6) M) pretreatment changed the phasic contractions to tonic contractions. Adenosine and its analogs (5'-N-ethyl-carboxamide adenosine, NECA and N6-L-phenyl-isopropyl adenosine, L-PIA), produced concentration-dependent relaxations of the tonic contractions and the order of potency was found to be: NECA greater than L-PIA greater than adenosine. 8-Phenyltheophylline (5 X 10(-6) M) antagonized the relaxations produced by adenosine and its analogs. The data suggest the existence of A2 adenosine receptor in human coronary arteries.

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Citations

Jul 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·A ContiE Ongini
Jan 2, 1989·European Journal of Pharmacology·M V RamagopalS J Mustafa
Oct 23, 1990·European Journal of Pharmacology·M H SabouniS J Mustafa
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Oct 20, 1992·European Journal of Pharmacology·S R MakujinaS J Mustafa
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Sep 15, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Dovenia S PonnothS Jamal Mustafa
Sep 29, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dovenia S PonnothS Jamal Mustafa
Dec 14, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dovenia S PonnothS Jamal Mustafa
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Dec 21, 2014·Purinergic Signalling·Geoffrey Burnstock, Amir Pelleg
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Dec 18, 2013·Pharmacological Reviews·Geoffrey Burnstock, Vera Ralevic
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May 11, 2002·American Journal of Physiology. Heart and Circulatory Physiology·M A Hassan TalukderS Jamal Mustafa
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Dec 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·M A Hassan TalukderS Jamal Mustafa
Sep 9, 2017·BioMed Research International·Maan T Khayat, Mohammed A Nayeem

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